The role of estrogen in intervertebral disc degeneration

被引：28

作者：

Jin, Lin-Yu ^{[1
,2
]}

Song, Xiao-Xing ^{[3
]}

Li, Xin-Feng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Dept Orthopaed Surg, Baoshan Branch,Renji Hosp, 1058 Huan Zheng Bei Rd, Shanghai 200444, Peoples R China

[2] Peking Univ, Peoples Hosp, Dept Spinal Surg, Beijing 100044, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Anesthesiol, Ruijin Hosp, Sch Med, 197 Ruijin Er Lu, Shanghai 200025, Peoples R China

来源：

STEROIDS | 2020年 / 154卷

基金：

中国国家自然科学基金;

关键词：

Estrogen; Intervertebral disc degeneration; Low back pain; Post menopause; NUCLEUS PULPOSUS CELLS; LOW-BACK-PAIN; DOWN-REGULATING MMP-3; BONE-MINERAL DENSITY; VERTEBRAL END-PLATE; ISSLS PRIZE WINNER; ANNULUS FIBROSUS; TNF-ALPHA; 17-BETA-ESTRADIOL PROTECTS; MATRIX METALLOPROTEINASES;

D O I：

10.1016/j.steroids.2019.108549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a crucial role in the metabolic dysfunction of others musculoskeletal structures, such as bone, muscle, and tendon. In this review, we attempt to describe the role of estrogen in IVDD and to summarize the proposed mechanisms in vivo and in vitro, as well as, to outline several interesting questions in this field.

引用

页数：11

共 160 条

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