MASS SPECTROMETRY ANALYSIS OF DRUGS OF ABUSE: CHALLENGES AND EMERGING STRATEGIES

被引：55

作者：

Borden, Scott A. ^{[1
,2
]}

Palaty, Jan ^{[3
]}

Termopoli, Veronica ^{[4
]}

Famiglini, Giorgio ^{[4
]}

Cappiello, Achille ^{[1
,4
]}

Gill, Chris G. ^{[1
,2
,5
,6
]}

Palma, Pierangela ^{[1
,4
]}

机构：

[1] Vancouver Isl Univ, Dept Chem, AERL, Nanaimo, BC V9R 5S5, Canada

[2] Univ Victoria, Dept Chem, Victoria, BC V8P 5C2, Canada

[3] LifeLabs Med Labs, Burnaby, BC V3W 1H8, Canada

[4] Univ Urbino Carlo Bo, Dept Pure & Appl Sci, LC MS Lab, I-61029 Urbino, Italy

[5] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[6] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

来源：

MASS SPECTROMETRY REVIEWS | 2020年 / 39卷 / 5-6期

关键词：

ambient ionization mass spectrometry; drugs of abuse; forensic; gas chromatography-mass spectrometry (GC-MS); liquid chromatography-mass spectrometry (LC-MS); toxicology; SOLID-PHASE MICROEXTRACTION; TIME-OF-FLIGHT; DESORPTION ELECTROSPRAY-IONIZATION; LIQUID-LIQUID MICROEXTRACTION; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; AMPHETAMINE-TYPE STIMULANTS; SONIC-SPRAY IONIZATION; MICROWAVE-ASSISTED DERIVATIZATION; INFORMATION-DEPENDENT ACQUISITION;

D O I：

10.1002/mas.21624

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Mass spectrometry has been the "gold standard" for drugs of abuse (DoA) analysis for many decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of mass spectrometry has seen significant developments in the field of DoA analysis. Mass spectrometry is particularly well suited to address the rapidly proliferating number of very high potency, novel psychoactive substances that are causing an alarming number of fatalities worldwide. This review surveys advancements in the areas of sample preparation, gas and liquid chromatography-mass spectrometry, as well as the rapidly emerging field of ambient ionization mass spectrometry. We have predominantly targeted literature progress over the past ten years and present our outlook for the future. (c) 2020 Periodicals, Inc. Mass Spec Rev

引用

页码：703 / 744

页数：42

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