Immune pathogenesis of hepatocellular carcinoma

被引：282

作者：

Nakamoto, Y ^{[1
]}

Guidotti, LG ^{[1
]}

Kuhlen, CV ^{[1
]}

Fowler, P ^{[1
]}

Chisari, FV ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, Div Expt Pathol, La Jolla, CA 92037 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1998年 / 188卷 / 02期

关键词：

cytotoxic T lymphocytes; hepatitis B virus; chronic hepatitis; hepatocellular carcinoma; transgenic mice;

D O I：

10.1084/jem.188.2.341

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV) infection. The pathogenetic mechanisms potentially responsible for HCC during chronic HBV infection are not well defined. This study demonstrates that chronic immune-mediated liver cell injury triggers the development of HCC in the absence of viral transactivation, insertional mutagenesis, and genotoxic chemicals. These results strongly suggest that the immune response to HBV is both necessary and sufficient to cause liver cancer during chronic HBV infection, and that all other procarcinogenic events associated with HCC are probably dependent on this process.

引用

页码：341 / 350

页数：10

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