Primary small cell carcinoma of the breast

被引：13

作者：

Hojo, Takashi ^{[1
]}

Kinoshita, Takayuki ^{[1
]}

Shien, Tadahiko ^{[1
]}

Terada, Kotoe ^{[1
]}

Hirose, Shigemichi ^{[2
]}

Isobe, You ^{[3
]}

Ikeuchi, Shunji ^{[3
]}

Kubochi, Kiyoshi ^{[3
]}

Matsumoto, Sumio ^{[3
]}

Sadako, Akashi-Tanaka ^{[1
]}

机构：

[1] Natl Canc Ctr, Breast Surg Div, Chuo Ku, Tokyo 1040045, Japan

[2] Natl Hosp Org Tokyo Med Ctr, Div Pathol, Meguro Ku, Tokyo 1528902, Japan

[3] Natl Hosp Org Tokyo Med Ctr, Div Surg, Meguro Ku, Tokyo 1528902, Japan

来源：

BREAST CANCER | 2009年 / 16卷 / 01期

关键词：

Breast; Small cell carcinoma; Chemotherapy; OF-THE-LITERATURE; NEUROENDOCRINE CARCINOMA; EXTRAPULMONARY; THERAPY; EXPERIENCE; CANCER;

D O I：

10.1007/s12282-008-0057-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary small cell carcinoma of the breast is a very rare disease, and only a few case reports have described small cell carcinoma of the breast that responds to chemotherapy. Here, we report a case of primary small cell carcinoma of the breast that was treated with surgery and chemotherapy for postoperative local recurrence in the chest wall and metastasis to the liver. The metastatic lesions showed a partial response (PR) to carboplatin and irinotecan, but did not respond to subsequent Taxotere and doxifluridine (5'-DFUR) treatment. We then treated the metastatic lesions with CBDCA and etoposide (VP-16), and were able to stop disease progression. Small cell carcinoma of the breast is as aggressive as its pulmonary counterpart. Therefore, the best therapy for primary small cell carcinoma of the breast may be surgery followed by adjuvant therapy similar to that recommended for small cell lung carcinoma.

引用

页码：68 / 71

页数：4

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