Caffeine and the dopaminergic system

被引：125
作者：
Cauli, O
Morelli, M
机构：
[1] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy
[2] Univ Cagliari, Ctr Excellence Neurobiol Dependence, I-09124 Cagliari, Italy
[3] Fdn Valenciana Invest Biomed, Neurobiol Lab, Valencia, Spain
来源：
BEHAVIOURAL PHARMACOLOGY | 2005年 / 16卷 / 02期
关键词：
caffeine; dopamine; nucleus accumbens; striatum; sensitization; adenosine; A(2A) receptors; tolerance; locomotion;
D O I：
10.1097/00008877-200503000-00001
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Caffeine is the most widely consumed psychostimulant substance, being self-administered throughout a wide range of conditions and present in numerous dietary products. Due to its widespread use and low abuse potential, caffeine is considered an atypical drug of abuse. The main mechanism of action of caffeine occurs via the blockade of adenosine A(1) and A(2A) receptors. Adenosine is a modulator of CNS neurotransmission and its modulation of dopamine transmission through A(2A) receptors has been implicated in the effects of caffeine. This review provides an updated summary of the results reported in the literature concerning the behavioural pharmacology of caffeine and the neurochemical mechanisms underlying the psychostimulant effects elicited by caffeine. The review focuses on the effects of caffeine mediated by adenosine A(2A) receptors and on the influence that pre-exposure to caffeine may exert on the effects of classical drugs of abuse.
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收藏
页码：63 / 77
页数：15
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