Inhibition of adhesion of Plasmodium falciparum-infected erythrocytes by structurally defined hyaluronic acid dodecasaccharides

被引：36

作者：

Chai, WG

Beeson, JG

Kogelberg, H

Brown, GV

Lawson, AM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Northwick Pk Hosp, Glycosci Lab, MRC, Harrow HA1 3UJ, Middx, England

[2] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Div Infect & Immun, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Med, Parkville, Vic 3050, Australia

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期

关键词：

D O I：

10.1128/IAI.69.1.420-425.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We recently reported that Plasmodium falciparum-infected erythrocytes (IRBCs) can adhere to hyaluronic acid (HA), which appears to be a receptor, in addition to chondroitin sulfate A (CSA), for parasite sequestration in the placenta. Further investigations of the nature and specificity of this interaction indicate that HA oligosaccharide fragments competitively inhibit parasite adhesion to immobilized purified HA in a size-dependent manner, with dodecasaccharides being the minimum size for maximum inhibition. Rigorously purified and structurally defined HA dodecasaccharides, free of contamination by CSA or other glycosaminoglycans, effectively inhibited IRBC adhesion to HA but not CSA, providing compelling evidence of a specific interaction between IRBCs and HA.

引用

页码：420 / 425

页数：6

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