Branched peptides for enzymatic supramolecular hydrogelation

被引：33

作者：

He, Hongjian ^{[1
]}

Wang, Huaimin ^{[1
]}

Zhou, Ning ^{[1
]}

Yang, Dongsik ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 01期

关键词：

RATIONAL DESIGN; SMALL MOLECULES; PROBES; CELLS;

D O I：

10.1039/c7cc08421h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we show the use of branched peptides (i.e., isopeptides) as the substrates of proteases for generating supramolecular hydrogels via enzymatically clipping the branch off the peptides. As the first report of using a protease to cut branched peptides to enable a molecular process for converting nanostructures, this work illustrates a fundamentally new molecular motif for exploring the applications of protease-instructed self-assembly for soft materials.

引用

页码：86 / 89

页数：4

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