Assembling photosensitive capsules by phthalocyanines and polyelectrolytes for photodynamic therapy

被引：21

作者：

Zeng, Yu ^{[2
]}

Wang, Xiao-Lei ^{[2
]}

Yang, Yun-Jie ^{[1
,2
]}

Chen, Jian-Feng ^{[1
]}

Fu, Jiwen ^{[1
]}

Tao, Xia ^{[2
]}

机构：

[1] Beijing Univ Chem Technol, Res Ctr, Minist Educ High Grav Engn & Technol, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, Key Lab Nanomat, Minist Educ, Beijing 100029, Peoples R China

来源：

POLYMER | 2011年 / 52卷 / 08期

关键词：

Aluminum phthalocyanine; Self-assembled capsules; Photodynamic therapy; SINGLET OXYGEN; GOLD NANOPARTICLES; MICROCAPSULES; ENCAPSULATION; PERMEABILITY; MICROSCOPY; SURFACES; MELANOMA; RELEASE; CHARGE;

D O I：

10.1016/j.polymer.2011.02.020

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A photosensitive capsule consisting of aluminum phthalocyanine tetrasulfonate chloride (AIPcS(4)Cl) and polyelectrolytes was fabricated by assembling of oppositely charged poly(allylamine hydrochloride) (PAH) and AlPcS4Cl onto the preformed capsules composed of poly(styrene sulfonate) (PSS) and PAH. UV visible absorption spectra, EDX spectrum and AFM images confirmed the successful deposition of AlPcS4Cl onto as-prepared hollow capsules. The assembled photosensitive capsules were found to remain intact and spherical morphology in the deposition process. The generation of cytotoxic singlet oxygen (O-1(2)) of photosensitive capsules under visible light irradiation (670 +/- 10 nm) was evidenced by ESR measurements and the oxidative reaction between the generated O-1(2) and a detector. In vitro cellular experiments showed that photosensitive capsules exhibited a good biocompatibility in the dark and a higher killing efficacy against MCF-7 cancer cells under visible light irradiation as compared with free AlPcS4Cl, which implies that the assembled photosensitive capsules might be potentially applicable in photodynamic therapy. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1766 / 1771

页数：6

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