Macaques Exhibit a Naturally-Occurring Depression Similar to Humans

被引:37
作者
Xu, Fan [1 ,2 ,3 ]
Wu, Qingyuan [1 ,2 ,3 ,4 ]
Xie, Liang [2 ,3 ,4 ]
Gong, Wei [1 ,2 ,3 ]
Zhang, Jianguo [1 ,2 ,3 ]
Zheng, Peng [2 ,3 ,4 ]
Zhou, Qinmin [2 ,3 ,4 ]
Ji, Yongjia [1 ,2 ,3 ]
Wang, Tao [1 ,2 ,3 ]
Li, Xin [2 ,3 ,4 ]
Fang, Liang [1 ,2 ,3 ]
Li, Qi [1 ,2 ,3 ]
Yang, Deyu [1 ,2 ,3 ]
Li, Juan [1 ,2 ,3 ]
Melgiri, Narayan D. [2 ,3 ]
Shively, Carol [5 ]
Xie, Peng [1 ,2 ,3 ,4 ]
机构
[1] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China
[2] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China
[3] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
[5] Wake Forest Sch Med, Dept Pathol, Winston Salem, NC USA
来源
SCIENTIFIC REPORTS | 2015年 / 5卷
基金
中国国家自然科学基金;
关键词
ANIMAL-MODELS; SOCIAL STRESS; MAJOR DEPRESSION; ANTIDEPRESSANTS; IDENTIFICATION; DYSFUNCTION; DISORDERS;
D O I
10.1038/srep09220
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors - do not realistically resemble the etiopathological development of depression, which occurs naturally in a social context. A non-human primate model that better reflects the social ethological aspects of depression would be more advantageous to investigating pathophysiological mechanisms and developing antidepressant therapeutics. Here, we describe and model a naturally-occurring depressive state in a non-human primate species, the cynomolgus monkey (Macaca fascicularis), in a realistic social ethological context and associate the depressed behavioral phenotype with significant serum metabolic perturbations. One to two subjects per stable social colony (1722 subjects) manifested a depressive phenotype that may be attributed to psychosocial stress. In accordance with rodent and human studies, the serum metabolic phenotype of depressed and healthy subjects significantly differed, supporting the model's face validity. However, application of the fast-acting antidepressant ketamine failed to demonstrate predictive validity. This study proposes a non-human primate depression model in a realistic social ethological context that can better approximate the psychosocial stressors underlying depression.
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收藏
页数:10
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