Genomic updates in understanding PTSD

被引：19
作者：
Sharma, Sumeet [1 ,2 ]
Ressler, Kerry J. [1 ,2 ,3 ]
机构：
[1] Emory Univ, Dept Psychiat & Behav Sci, Neurosci Program, Atlanta, GA 30322 USA
[2] McLean Hosp, Div Depress & Anxiety, Belmont, MA 02478 USA
[3] Harvard Med Sch, Boston, MA USA
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2019年 / 90卷
关键词：
Gene-by-environment interaction; Stress; Anxiety; PTSD; Depression; Epigenetic; Trauma; POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD TRAUMA; ENVIRONMENT INTERACTION; ADCYAP1R1; GENOTYPE; OBSTETRIC COMPLICATIONS; WIDE ASSOCIATION; BIPOLAR DISORDER; CANDIDATE GENES; COMPLEX TRAITS; PAC1; RECEPTOR;
D O I：
10.1016/j.pnpbp.2018.11.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Twin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.
引用
收藏
页码：197 / 203
页数：7
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