Resolution of diffuse skin and systemic Kaposi's sarcoma in a renal transplant recipient after introduction of everolimus: a case report

被引：19

作者：

Detroyer, D. ^{[1
]}

Deraedt, K. ^{[2
]}

Schoffski, P. ^{[3
]}

Hauben, E. ^{[2
]}

Lagrou, K. ^{[4
]}

Naesens, M. ^{[1
]}

Delforge, M. -L. ^{[5
]}

Kuypers, D. ^{[1
]}

机构：

[1] UZ Leuven, Dept Nephrol, B-3000 Leuven, Belgium

[2] UZ Leuven, Dept Pathol, B-3000 Leuven, Belgium

[3] UZ Leuven, Dept Oncol, B-3000 Leuven, Belgium

[4] UZ Leuven, Dept Lab Med & Microbiol, B-3000 Leuven, Belgium

[5] Univ Libre Bruxelles, Hop Erasme, Dept Microbiol, Brussels, Belgium

来源：

TRANSPLANT INFECTIOUS DISEASE | 2015年 / 17卷 / 02期

关键词：

mTOR inhibitor; Kaposi's sarcoma; immunosuppression; Kaposi's sarcoma herpesvirus; renal transplantation; Pyrenochaeta romeroi; SIROLIMUS; RAPAMYCIN;

D O I：

10.1111/tid.12357

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We present a case report of a patient with diffuse skin and systemic Kaposi's sarcoma (KS), 1year after renal transplantation. A concomitant Pyrenochaeta romeroi granuloma of the right hallux was diagnosed and illustrated an important immunodysfunction in our patient. Four months after reduction in immunosuppression and switch to everolimus, a total regression of the KS was observed. Reduction in the immunosuppression and treatment with terbinafine cleared the P.romeroi infection, while lowering immunosuppression and changing the type of immunosuppressive therapy were important steps in the successful management of the KS. In recent years, evidence of the antitumor effects of everolimus is increasing: total regression of KS in combination with renal function preservation in renal graft recipients is possible with mammalian target of rapamycin (mTOR) inhibitor-based regimens. In addition, with increasing numbers of human immunodeficiency virus-positive transplant recipients, mTOR inhibitors may play a more crucial role in the management of KS.

引用

页码：303 / 307

页数：5

共 20 条

[1] Kaposi's sarcoma [J].