Synthesis of glycopeptide dendrimer by a convergent method

被引：21

作者：

Ozawa, Chinatsu ^{[1
]}

Hojo, Hironobu ^{[1
]}

Nakahara, Yuko ^{[1
]}

Katayama, Hidekazu ^{[1
]}

Nabeshima, Kazuki ^{[2
]}

Akahane, Toshiaki ^{[3
]}

Nakahara, Yoshiaki ^{[1
]}

机构：

[1] Tokai Univ, Inst Glycotechnol, Dept Appl Biochem, Kanagawa 2591292, Japan

[2] Fukuoka Univ Hosp, Dept Pathol, Fukuoka 8140180, Japan

[3] ATTO Corp, Tokyo 1138425, Japan

来源：

TETRAHEDRON | 2007年 / 63卷 / 39期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.tet.2007.07.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycopeptide thioester comprising the sequence of extracellular matrix metalloproteinase inducer (emmprin) (34-58) was prepared and condensed with a dendrimer core having eight amino groups by the thioester method. The desired product, a glycopeptide dendrimer carrying an N-linked core pentasaccharide of about 30 kDa, was successfully isolated by preparative electrophoresis and characterized by mass analysis. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：9685 / 9690

页数：6

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