A versatile, immobilized gold catalyst for the reductive amination of aldehydes in batch and flow

被引：19

作者：

Carrillo, Adela I. ^{[1
]}

Llanes, Patricia ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Inorgan & Organ, Barcelona 08080, Spain

来源：

REACTION CHEMISTRY & ENGINEERING | 2018年 / 3卷 / 05期

关键词：

CARBONYL-COMPOUNDS; MESOPOROUS SILICA; SECONDARY-AMINES; CHEMOSELECTIVE REDUCTION; RUTHENIUM NANOPARTICLES; HETEROGENEOUS CATALYSTS; TRANSFER HYDROGENATION; HIGHLY EFFICIENT; MILD CONDITIONS; NITRO-COMPOUNDS;

D O I：

10.1039/c8re00101d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and environmentally friendly catalytic route for the reductive amination of carbonyl compounds has been designed. First, a one-pot procedure has been followed for the synthesis and incorporation of gold nanoparticles (AuNPs) into a mesoporous silica solid by using light as an abundant and clean energy source. Then, the as-prepared material has been successfully employed as a heterogeneous catalyst in the production of secondary and tertiary amines by reductive amination using Ph(Me)(2)SiH as the reducing agent. The endurance of the catalyst has been demonstrated in batch, and a continuous flow process allowing the safe preparation of multigram amounts of reductive amination products (accumulated TON = 434 in 18 h operation involving 6 sequential examples) has been implemented. The scope of the reaction has also been extended to the synthesis of more challenging active pharmaceutical ingredients (APIs), such as indoprofen precursors and biomass-derived products, which were obtained in good to excellent yields.

引用

页码：714 / 721

页数：8

共 60 条

[1] Au/ZnO and Au/Fe2O3 catalysts for CO oxidation at ambient temperature:: comments on the effect of synthesis conditions on the preparation of high activity catalysts prepared by coprecipitation [J].