Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa

被引：45

作者：

Arung, Enos Tangke ^{[1
,2
]}

Furuta, Shoko ^{[3
]}

Ishikawa, Hiroya ^{[3
]}

Kusuma, Irawan Wijaya ^{[2
]}

Shimizu, Kuniyoshi ^{[1
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Dept Forest & Forest Prod Sci, Fac Agr, Fukuoka 8128581, Japan

[2] Mulawarman Univ, Dept Forest Prod Technol, Fac Forestry, Samarinda 75123, Indonesia

[3] Fukuoka Womens Univ, Dept Nutr & Hlth Sci, Fac Human Environm Sci, Fukuoka 8138529, Japan

来源：

FOOD CHEMISTRY | 2011年 / 124卷 / 03期

基金：

日本学术振兴会;

关键词：

Allium cepa; Red onion; Quercetin derivatives; Anti-melanogenesis; Antioxidant; MELANOMA-CELLS; ANTIOXIDANT PROPERTIES; HUMAN MELANOCYTES; FLAVONOIDS; TYROSINASE; CAPACITY; OXIDATION; ASSAY; L;

D O I：

10.1016/j.foodchem.2010.07.067

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In an effort to find a new whitening agent, we have found that the methanol extract of the dried skin of Allium cepa showed inhibition of melanin formation. Bioassay-guided fractionation led to the isolation of quercetin (1) and quercetin 4'-O-beta-glucoside (3) from A. cepa as the inhibitors of melanin formation in B16 melanoma cells with IC50 values of 26.5 and 131 mu M, respectively. In addition, we evaluated the effect of some quercetin derivatives, such as isoquercitrin (2), quercetin 3,4'-O-diglucoside (4), rutin (5) and hyperin (6) on B16 melanoma cells. These quercetin derivatives did not show any inhibition of melanin formation. Furthermore, the ORAC values of compounds 1-6 were 7.64, 8.65, 4.82, 4.32, 8.17 and 9.34 mu mol trolox equivalents/mu mol. respectively. Dried skin of red onion showed inhibitory activity against melanin formation in B16 melanoma cells, as well as antioxidant properties. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1024 / 1028

页数：5

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