Multifunctional porous silica nanoparticles for dual responsive drug release

被引：6

作者：

Bo, Xindang ^{[1
,2
]}

Zhang, Qianqian ^{[1
]}

Li, Xinli ^{[1
]}

Zhao, Yanbao ^{[1
]}

机构：

[1] Henan Univ, Engn Res Ctr Nanomat, Kaifeng 475004, Peoples R China

[2] Henan Vocat Coll Appl Technol, Dept Chem Engn, Zhengzhou 450042, Peoples R China

来源：

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY | 2020年 / 93卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Dual responsive; Drug delivery; Carbon dots; Fluorescent monitoring; DELIVERY SYSTEM; STIMULI; NANOCARRIERS; FLUORESCENCE; NANOSPHERES; DOTS; SIZE;

D O I：

10.1007/s10971-019-05133-w

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous silica nanoparticles (PSNs) were prepared by hydrolysis of tetraethyl orthosilicate and 3-aminopropyltriethoxysilane in emulsion. The PSN carriers with hierarchical pores are suitable for loading drug and controlling release. Chitosan molecules were used to close all drug-loaded pores to reduce the premature release. Hyaluronic acid (HA) modified carbon dots (CDHA) are further used to encapsulate carriers, which endow them enzyme responsiveness. The PSN carriers display pH/enzyme-responsive release and the drug release follows the first-order kinetics model. CDHA can be used not only for fluorescent marker for carriers, but also for qualitative monitoring of the drug release.

引用

页码：324 / 331

页数：8

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