Proliferation but Not Migration Is Associated with Blood Vessels during Development of the Rostral Migratory Stream

被引：24

作者：

Nie, Kai ^{[1
]}

Molnar, Zoltan ^{[1
]}

Szele, Francis G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

来源：

DEVELOPMENTAL NEUROSCIENCE | 2010年 / 32卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Subventricular zone; Telencephalon; Olfactory bulb; Phosphohistone; 3; Blood vessels; VASCULAR NICHE; SUBVENTRICULAR ZONE; ADULT; CELLS; NEUROGENESIS; ANGIOGENESIS; SURVIVAL; SCAFFOLD; SUPPORT; BRAIN;

D O I：

10.1159/000301135

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood vessels play a critical role in regulating neural stem cell proliferation and migration. We show here that blood vessels became progressively aligned in the direction of the rostral migratory stream (RMS) from embryonic day 14 to postnatal day 4. Dividing cells revealed by phosphohistone H3+ immunoreactivity were statistically closer to isolectin B4+ blood vessels than predicted by chance in the emerging RMS. The close proximity of blood vessels and H3+ cells was consistent regardless of the age of the RMS and was strikingly similar to the embryonic cerebral cortex. In contrast to the adult RMS, we found no evidence for preferential juxtaposition of migratory doublecortin-positive neuroblasts and vasculature in the neonatal RMS. Our work provides an important framework for understanding the precise mechanism behind regulation of proliferation. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：163 / 172

页数：10

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