Two smoking-related lesions in the same pulmonary lobe of squamous cell carcinoma and pulmonary Langerhans cell histiocytosis: A case report

被引：2

作者：

Gencer, Aysegul ^{[1
]}

Ozcibik, Gizem ^{[2
]}

Karakas, Fatma Gulsum ^{[1
]}

Sarbay, Ismail ^{[2
]}

Batur, Sebnem ^{[3
]}

Borekci, Sermin ^{[1
]}

Turna, Akif ^{[2
]}

机构：

[1] Istanbul Univ Cerrahpasa, Dept Pulm Dis, Cerrahpasa Med Fac Campus,Kocamustafapasa St 53, TR-34098 Istanbul, Turkey

[2] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Thorac Surg, TR-34098 Istanbul, Turkey

[3] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Pathol, TR-34098 Istanbul, Turkey

来源：

WORLD JOURNAL OF CLINICAL CASES | 2022年 / 10卷 / 19期

关键词：

Pulmonary Langerhans cell histiocytosis; Lung cancer; Squamous cell carcinoma; BRAF; Mitogen-activated protein kinase; Case report; MUTATIONS; MANAGEMENT;

D O I：

10.12998/wjcc.v10.i19.6722

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung. CASE SUMMARY A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH. CONCLUSION Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.

引用

页码：6722 / 6727

页数：7

共 16 条

[1] BRAF-Mutant Pulmonary Langerhans Cell Histiocytosis Mimicking Recurrence of Early-Stage KRAS-Mutant Lung Adenocarcinoma [J].

Alden, Stephanie L. ;

Swanson, Scott J. ;

Nishino, Mizuki ;

Sholl, Lynette M. ;

Awad, Mark M. .

JTO CLINICAL AND RESEARCH REPORTS, 2021, 2 (02)

[2] Langerhans-Cell Histiocytosis [J].

Allen, Carl E. ;

Merad, Miriam ;

McClain, Kenneth L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (09) :856-868

[3] Recurrent BRAF mutations in Langerhans cell histiocytosis [J].

Badalian-Very, Gayane ;

Vergilio, Jo-Anne ;

Degar, Barbara A. ;

MacConaill, Laura E. ;

Brandner, Barbara ;

Calicchio, Monica L. ;

Kuo, Frank C. ;

Ligon, Azra H. ;

Stevenson, Kristen E. ;

Kehoe, Sarah M. ;

Garraway, Levi A. ;

Hahn, William C. ;

Meyerson, Matthew ;

Fleming, Mark D. ;

Rollins, Barrett J. .

BLOOD, 2010, 116 (11) :1919-1923

[4] Clinical implications of oncogenic mutations in pulmonary Langerhans cell histiocytosis [J].

Brown, Noah A. ;

Elenitoba-Johnson, Kojo S. J. .

CURRENT OPINION IN PULMONARY MEDICINE, 2018, 24 (03) :281-286

[5] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[6] OPEN BIOPSY FOR CHRONIC DIFFUSE INFILTRATIVE LUNG-DISEASE - CLINICAL, ROENTGENOGRAPHIC, AND PHYSIOLOGICAL CORRELATIONS IN 502 PATIENTS [J].

GAENSLER, EA ;

CARRINGTON, CB .

ANNALS OF THORACIC SURGERY, 1980, 30 (05) :411-426

[7] A Clinicopathologic Review and Molecular Pathogenetic Update [J].

Harmon, Charles M. ;

Brown, Noah .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2015, 139 (10) :1211-1214

[8] Genetic landscape of adult Langerhans cell histiocytosis with lung involvement [J].

Jouenne, Fanelie ;

Chevret, Sylvie ;

Bugnet, Emmanuelle ;

Clappier, Emmanuelle ;

Lorillon, Gwenael ;

Meignin, Veronique ;

Sadoux, Aurelie ;

Cohen, Shannon ;

Haziot, Alain ;

How-Kit, Alexandre ;

Kannengiesser, Caroline ;

Lebbe, Celeste ;

Gossot, Dominique ;

Mourah, Samia ;

Tazi, Abdellatif .

EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (02)

[9] Development of pulmonary Langerhans cell histiocytosis in a patient with established adenocarcinoma of the lung [J].

Kalchiem-Dekel, Or ;

Paulk, Adina ;

Kligerman, Seth J. ;

Burke, Allen P. ;

Shah, Nirav G. ;

Dixon, Renee K. .

JOURNAL OF THORACIC DISEASE, 2017, 9 (12) :E1079-E1083

[10] Need for a cooperative study: Pulmonary Langerhans cell histiocytosis and its management in adults [J].

McClain, KL ;

Gonzalez, JM ;

Jonkers, R ;

De Juli, E ;

Egeler, M .

MEDICAL AND PEDIATRIC ONCOLOGY, 2002, 39 (01) :35-39

← 1 2 →