Transition-Metal-Free Stereospecific Oxidative Annulative Coupling of Indolines with Aziridines

被引：11

作者：

Karjee, Pallab ^{[1
]}

Sarkar, Tanumay ^{[1
]}

Kar, Subhradeep ^{[1
]}

Punniyamurthy, Tharmalingam ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 12期

关键词：

C-H AMIDATION; MESO-AZIRIDINES; FREE AMINATION; FUNCTIONALIZATION; HETEROCYCLES; CATALYST; IMINES; ACCESS;

D O I：

10.1021/acs.joc.0c00899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tandem C-N bond formation for the oxidative annulation of indolines with aziridines is accomplished employing the combination of DDQ and NaOCl at ambient conditions. Optically active aziridine can be coupled with high enantiomeric purity (>99% ee). The substrate scope, stereocontrol with the enantioenriched substrate, and scale-up are the important practical advantages.

引用

页码：8261 / 8270

页数：10

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