The role of SirT1 in muscle mitochondrial turnover

被引：38
|
作者：
Menzies, Keir J. [2 ,3 ]
Hood, David A. [1 ,2 ,3 ]
机构：
[1] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada
[2] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada
[3] York Univ, Muscle Hlth Res Ctr, Toronto, ON M3J 1P3, Canada
来源：
MITOCHONDRION | 2012年 / 12卷 / 01期
基金：
加拿大健康研究院;
关键词：
SirT1; AMPK; Nampt; Mitochondrial biogenesis; Autophagy; Circadian rhythm; ACTIVATED PROTEIN-KINASE; GAMMA COACTIVATOR-1-ALPHA EXPRESSION; SMALL-MOLECULE ACTIVATORS; LIFE-SPAN EXTENSION; SKELETAL-MUSCLE; CALORIE RESTRICTION; AUTOREGULATORY LOOP; OXIDATIVE CAPACITY; DEACETYLASE SIRT1; PGC-1-ALPHA GENE;
D O I：
10.1016/j.mito.2011.03.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SirT1 protein has received considerable attention for its potential role in longevity. It has been described as a metabolic protein that can sense and communicate the energy status of a cell to key mechanisms of mitochondrial regulation and energy production. These mechanisms include the biogenesis of mitochondria, the clearance of damaged organelles, and the physiological rhythmicity of gene expression. Elucidation of the pathways involved in SirT1-mediated mitochondrial turnover ultimately allow for the design of pharmaceuticals for the treatment of degenerative processes that are associated with metabolic and mitochondrial health. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：5 / 13
页数：9
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