FcεRI- and MRGPRX2-evoked acute degranulation responses are fully additive in human skin mast cells

被引:26
作者
Babina, Magda [1 ,2 ,3 ,4 ,5 ]
Wang, Zhao [1 ,2 ,3 ,4 ,6 ]
Li, Zhuoran [1 ,2 ,3 ,4 ,5 ]
Franke, Kristin [1 ,2 ,3 ,4 ,5 ]
Guhl, Sven [1 ,2 ,3 ,4 ,5 ]
Artuc, Metin [1 ,2 ,3 ,4 ,5 ]
Zuberbier, Torsten [1 ,2 ,3 ,4 ,5 ]
机构
[1] Charite Univ Med Berlin, Inst Allergol, Berlin, Germany
[2] Free Univ Berlin, Berlin, Germany
[3] Humboldt Univ, Berlin, Germany
[4] Berlin Inst Hlth, Berlin, Germany
[5] Fraunhofer Inst Translat Med & Pharmacol ITMP All, Berlin, Germany
[6] Xi An Jiao Tong Univ, Northwest Hosp, Affiliated Hosp 2, Dept Dermatol, Xian, Peoples R China
关键词
anaphylaxis; drug allergy; Fc epsilon RI; mast cell; MRGPRX2;
D O I
10.1111/all.15270
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1906 / 1909
页数:4
相关论文
共 7 条
[1]   Allergic FcεRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF [J].
Babina, M. ;
Guhl, S. ;
Artuc, M. ;
Zuberbier, T. .
ALLERGY, 2018, 73 (01) :256-260
[2]  
Babina M., 2020, ITCH, V5, pe32, DOI [10.1097/itx.0000000000000032, DOI 10.1097/ITX.0000000000000032]
[3]   MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway [J].
Babina, Magda ;
Wang, Zhao ;
Roy, Saptarshi ;
Guhl, Sven ;
Franke, Kristin ;
Artuc, Metin ;
Ali, Hydar ;
Zuberbier, Torsten .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2021, 141 (05) :1286-+
[4]   MRGPRX2 is negatively targeted by SCF and IL-4 to diminish pseudo-allergic stimulation of skin mast cells in culture [J].
Babina, Magda ;
Wang, Zhao ;
Artuc, Metin ;
Guhl, Sven ;
Zuberbier, Torsten .
EXPERIMENTAL DERMATOLOGY, 2018, 27 (11) :1298-1303
[5]   Different activation signals induce distinct mast cell degranulation strategies [J].
Gaudenzio, Nicolas ;
Sibilano, Riccardo ;
Marichal, Thomas ;
Starkl, Philipp ;
Reber, Laurent L. ;
Cenac, Nicolas ;
McNeil, Benjamin D. ;
Dong, Xinzhong ;
Hernandez, Joseph D. ;
Sagi-Eisenberg, Ronit ;
Hammel, Ilan ;
Roers, Axel ;
Valitutti, Salvatore ;
Tsai, Mindy ;
Espinosa, Eric ;
Galli, Stephen J. .
JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (10) :3981-3998
[6]   MRGPRX2 and Adverse Drug Reactions [J].
McNeil, Benjamin D. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[7]   The pseudoallergen receptor MRGPRX2 on peripheral blood basophils and eosinophils: Expression and function [J].
Wedi, Bettina ;
Gehring, Manuela ;
Kapp, Alexander .
ALLERGY, 2020, 75 (09) :2229-2242