The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model

被引：20
|
作者：
Yosten, Gina L. C. [1 ]
Kolar, Grant R. [2 ]
机构：
[1] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA
[2] St Louis Univ, Sch Med, Dept Pathol, St Louis, MO 63104 USA
来源：
PHYSIOLOGY | 2015年 / 30卷 / 04期
关键词：
O-2-INDUCED ATP RELEASE; PROTEIN-KINASE-C; RECEPTOR; INSULIN; BINDING; COMPLICATIONS; DYSFUNCTION; ALPHA; CELLS; ERYTHROCYTES;
D O I：
10.1152/physiol.00008.2015
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.
引用
收藏
页码：327 / 332
页数：6
相关论文
共 50 条
  • [21] Solution structure of human proinsulin C-peptide
    Munte, CE
    Vilela, L
    Kalbitzer, HR
    Garratt, RC
    FEBS JOURNAL, 2005, 272 (16) : 4284 - 4293
  • [22] SYNTHESIS AND RADIOIMMUNOASSAY OF C-PEPTIDE OF HUMAN PROINSULIN
    YANG, SZ
    LIU, Z
    LU, Z
    HUANG, WD
    CHEN, YN
    MA, AQ
    MA, YL
    JIANG, RQ
    YE, JX
    NIU, JY
    KEXUE TONGBAO, 1982, 27 (09): : 1004 - 1010
  • [23] RENAL METABOLISM OF PROINSULIN, INSULIN AND C-PEPTIDE
    RABKIN, R
    ROSS, B
    RUBENSTEIN, A
    KIDNEY INTERNATIONAL, 1975, 8 (06) : 489 - 489
  • [24] Insights Into the Physiology of C-peptide
    Vejrazkova, Daniela
    Vankova, Marketa
    Lukasova, Petra
    Vcelak, Josef
    Bendlova, Bela
    PHYSIOLOGICAL RESEARCH, 2020, 69 : S237 - S243
  • [25] CONFORMATIONAL POTENTIAL OF PORCINE PROINSULIN C-PEPTIDE
    VOGT, HP
    WOLLMER, A
    NAITHANI, VK
    ZAHN, H
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1976, 357 (01): : 107 - 116
  • [26] C-PEPTIDE AND PROINSULIN AFTER ORAL GLUCOSE
    HEDING, LG
    KASPERSKACZYZYKOWA, T
    ACTA MEDICA SCANDINAVICA, 1980, : 33 - 36
  • [27] Mechanisms of action and therapeutic potential of proinsulin C-peptide
    A. O. Shpakov
    Journal of Evolutionary Biochemistry and Physiology, 2017, 53 : 180 - 190
  • [28] Proinsulin C-peptide does not bind to lipid vesicles
    Henriksson, M
    Johansson, J
    Shafqat, J
    Tally, M
    Wahren, J
    Jörnvail, H
    DIABETOLOGIA, 1999, 42 : A200 - A200
  • [29] Proinsulin C-peptide Regulates Ribosomal RNA Expression
    Lindahl, Emma
    Nyman, Ulrika
    Zaman, Farasat
    Palmberg, Carina
    Cascante, Anna
    Shafqat, Jawed
    Takigawa, Masaharu
    Savendahl, Lars
    Jorvall, Hans
    Joseph, Bertrand
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (05) : 3462 - 3469
  • [30] Proinsulin C-peptide interferes with insulin fibril formation
    Landreh, Michael
    Stukenborg, Jan-Bernd
    Willander, Hanna
    Soder, Olle
    Johansson, Jan
    Jornvall, Hans
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 418 (03) : 489 - 493
12345