Copper-free azide-alkyne cycloadditions: New insights and perspectives

被引：293

作者：

Lutz, Jean-Francois ^{[1
]}

机构：

[1] Fraunhofer Inst Appl Polymer Res, Res Grp Nanotechnol Life Sci, D-14476 Potsdam, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

关键词：

alkynes; azides; bioconjugation; biotechnology; cycloaddition;

D O I：

10.1002/anie.200705365

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Clicking without copper: Copper-mediated azide-alkyne "click" cycloadditions (CuAAC) play a central role in contemporary synthetic chemistry but rely on transition-metal catalysts, which hamper their adoption in some biological applications. Recently, the strain-promoted and fluorine-activated cycloaddition of cyclooctynes and organic azides (see picture) was proposed as an interesting metal-free alternative to CuAAC. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2182 / 2184

页数：3

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