Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C

被引：26

作者：

Honma, Atsushi ^{[1
]}

Koyama, Tomoyuki ^{[1
]}

Yazawa, Kazunaga ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Grad Sch Marine Sci & Technol, Minato Ku, Tokyo 1088477, Japan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2011年 / 26卷 / 02期

关键词：

Acer pycnanthum; diabetes mellitus; a-glucosidase inhibitory effect; ginnalin B; ginnalin C; ALPHA-GLUCOSIDASE; EXTRACT; LEAVES;

D O I：

10.3109/14756366.2010.486795

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the alpha alpha-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5-anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.</.

引用

页码：176 / 180

页数：5

共 37 条

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