Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

被引：1002

作者：

Skrivankova, Veronika W. ^{[1
]}

Richmond, Rebecca C. ^{[2
,3
]}

Woolf, Benjamin A. R. ^{[2
,4
]}

Davies, Neil M. ^{[2
,3
,5
]}

Swanson, Sonja A. ^{[6
]}

VanderWeele, Tyler J. ^{[7
]}

Timpson, Nicholas J. ^{[2
,3
]}

Higgins, Julian P. T. ^{[3
,8
]}

Dimou, Niki ^{[9
]}

Langenberg, Claudia ^{[10
,11
]}

Loder, Elizabeth W. ^{[12
,13
]}

Golub, Robert M. ^{[14
,15
]}

Egger, Matthias ^{[1
,3
,16
]}

Smith, George Davey ^{[2
,3
,8
]}

Richards, J. Brent ^{[17
,18
,19
,20
,21
]}

机构：

[1] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[2] Univ Bristol, Med Res Council Integrat Epidemiol Unit, Bristol, Avon, England

[3] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[4] Univ Bristol, Dept Psychol Sci, Bristol, Avon, England

[5] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

[6] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[7] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[8] NIHR Bristol Biomed Res Ctr, Bristol, Avon, England

[9] Int Agcy Res Canc, Nutr & Metab Branch, Lyon, France

[10] Charite Univ Med Berlin, Berlin Inst Hlth, Berlin, Germany

[11] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[12] Harvard Med Sch, Boston, MA 02115 USA

[13] The BMJ, London, England

[14] JAMA, Chicago, IL USA

[15] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[16] Univ Cape Town, Ctr Infect Dis Epidemiol & Res, Cape Town, South Africa

[17] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Med, Montreal, PQ, Canada

[18] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Human Genet, Montreal, PQ, Canada

[19] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Epidemiol, Montreal, PQ, Canada

[20] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Biostat, Montreal, PQ, Canada

[21] Univ London, Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2021年 / 375卷

基金：

英国惠康基金; 美国国家卫生研究院; 英国经济与社会研究理事会; 瑞士国家科学基金会; 加拿大健康研究院; 英国医学研究理事会;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW TRANSPLANTATION; CAUSAL INFERENCE; INSTRUMENTAL VARIABLES; GENETIC-VARIANTS; BIAS; RISK; ASSOCIATION; GUIDELINES; IDENTIFICATION;

D O I：

10.1136/bmj.n2233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation) assists authors in reporting their MR research clearly and transparently. Adopting STROBE-MR should help readers, reviewers, and journal editors evaluate the quality of published MR studies. This article explains the 20 items of the STROBE MR checklist, along with their meaning and rationale, using terms defined in a glossary. Examples of transparent reporting are used for each item to illustrate best practices.

引用

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