Synthesis and spectroscopic studies of some hydrogenated thiazolo[2,3-a]isoquinolines

被引：17

作者：

Rozwadowska, MD ^{[1
]}

Sulima, A ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

来源：

TETRAHEDRON | 2001年 / 57卷 / 16期

关键词：

thiazolo [2,3-a]isoquinolines; synthesis; IR; H-1; NMR; C-13; MS;

D O I：

10.1016/S0040-4020(01)00224-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dihydro-5H-thiazolo[2,3-a]isoquinolinones (1-6) and tetrahydro-5H-thiazolo[2,3a]isoquinoline (7-12) have been prepared from 3,4-dihydroisoquinoline derivatives under the action of a-mercapto alkanoic acids or ethylene sulfide, respectively. In the synthesis of compounds 2 and 5 isothiocarbostril (13) and N-thioacetyl-beta -phenylethylamine derivatives (14), respectively, were also used as substrates and treated with bromoacetic acid derivatives. Spectral characteristics (IR, H-1, C-13 NMR and MS) of compounds 1-12 are presented. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3499 / 3506

页数：8

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