Synthesis and antimicrobial evaluation of some 4-quinolinylazo-N-pyrimidinyl benzenesulfonamide derivatives

被引：3

作者：

Fadda, Ahmed A. ^{[1
]}

Mohammed, Aya R. ^{[1
]}

Abdel-Galil, Ebrahim ^{[1
]}

机构：

[1] Mansoura Univ, Fac Sci, Chem Dept, El Gomhoria St, ET-35516 Mansoura, Egypt

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2020年 / 10卷 / 01期

关键词：

Sulfonamides; 8-Hydroxyquinoline; Chloroacetyl chloride; Malononitrile; Antimicrobial activity; BIOLOGICAL EVALUATION; CARBON-STEEL; ANTIBACTERIAL; INHIBITION; CORROSION; THIAZOLE; QUINOLINES; THIOPHENE; PYRIDINE;

D O I：

10.33263/BRIAC101.846852

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Ten new compounds of quinoline clubbed with sulfonamide moiety were synthesized to be used as antimicrobial agents. Therefore, the diazotized N-(pyrimidin-2-yl)-benzenesulfonamide was diazocoupled with 8-hydroxyquinoline to furnish 4-(8-hydroxyquinolin-5-yl)-N(pyrimidin-2-yl)benzenesulfonamide(3) which underwent chloroacetylation by chloroacetyl chloride to give the corresponding O-chloroacetylated product 6. The reactions of quinolinyl 2-chloroacetate derivative 6 with different nucleophiles (ethyl 2-mercaptoacetate,2-mercapto-4,6-dimethylnicotinonitrile, o-aminothiophenol and/or malononitrile) were studied and utilized to pick up various heterocyclic systems 7, 10, 12 and 14. The chemical structures of newly prepared quinoline-containing scaffolds have been confirmed based on their spectral data (IR, 1H NMR and MS) and have been tested for their antimicrobial activity. The results showed that compounds 5d, 6, 7 and 14 displayed the highest activity against Gram-positive bacteria..

引用

页码：4846 / 4852

页数：7

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