Detection of multiple hepatitis C virus genotypes in a cohort of injecting drug users

被引：30

作者：

Bowden, S

McCaw, R

White, PA

Crofts, N

Aitken, CK

机构：

[1] Macfarlane Burnet Inst Med Res & Publ Hlth, Epidemiol & Social Res Program, Melbourne, Vic 3001, Australia

[2] Univ New S Wales, Fac Sci, Sch Biotechnol & Biol Sci, Sydney, NSW, Australia

[3] Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia

[4] Macfarlane Burnet Inst Med Res & Publ Hlth, Ctr Harm Reduct, Melbourne, Vic 3001, Australia

来源：

JOURNAL OF VIRAL HEPATITIS | 2005年 / 12卷 / 03期

关键词：

drug injectors; hepatitis C virus; multiple genotypes; prevalence;

D O I：

10.1111/j.1365-2893.2005.00592.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Multiple genotypes of the hepatitis C virus (HCV) were detected in five of 138 HCV RNA positive injecting drug users (IDUs) recruited in Melbourne, Australia. Two were detected by combined LiPA and core and NS5a region sequencing, and three more ( selected for testing due to their high- risk behaviour) by heteroduplex mobility analysis. We conclude that the true prevalence of mixed infection in IDUs is undoubtedly higher than the 3.6% ( five of 138) we observed, and is underestimated by LiPA, the most common method of genotyping. As responsiveness to HCV treatment varies significantly with genotype, a high prevalence of mixed HCV infections in IDUs must diminish overall treatment efficacy and lessen our ability to reduce the burden of HCV- related disease.

引用

页码：322 / 324

页数：3

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