Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats

被引：101

作者：

Li, QH ^{[1
]}

Fu, CL ^{[1
]}

Rui, YK ^{[1
]}

Hu, GH ^{[1
]}

Cai, TY ^{[1
]}

机构：

[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2005年 / 60卷 / 01期

基金：

中国国家自然科学基金;

关键词：

activity-guided isolation; hypoglycemic activity; insulin; protein-bound polysaccharide; pumpkin;

D O I：

10.1007/s11130-005-2536-x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

To investigate hypoglycemic substances from pumpkin. protein-bound polysaccharide was isolated by activity-guided isolation from water soluble substances of the fruits. The protein-bound polysaccharide from pumpkin fruits (PBPP) was identified to consist mainly of polysaccharide (approximately 41.21%) and protein (approximately 10.13%) by anthrone test and Lowry-Folin test. Different closes of PBPP were evaluated for hypoglycemic activity and the effect on serum insulin levels in alloxan diabetic rats. The results indicated that PBPP can obviously increase the levels of serum insulin, reduce the blood glucose levels and improve tolerance of glucose. The hypoglycemic effect of big close PBPP group (1000 mg/kg body weight) excelled that of small dose PBPP group (500 mg/kg body weight) and antidiabetic agent group. The results suggest that the hypoglycemic effect of PBPP depends on the dose and PBPP possesses the possibility of being developed from a new antidiabetic agent.

引用

页码：13 / 16

页数：4

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