Common pathogenic pathways in melanoma and Parkinson disease

被引：33

作者：

Paisan-Ruiz, Coro ^{[1
,2
,3
,4
]}

Houlden, Henry ^{[4
]}

机构：

[1] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA

[4] UCL Inst Neurol, Mol Neurosci Dept, London WC1N 3BG, England

来源：

NEUROLOGY | 2010年 / 75卷 / 18期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; ALPHA-SYNUCLEIN; RISK; TYROSINASE; CANCER; DOPA;

D O I：

10.1212/WNL.0b013e3181fb4466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is growing evidence in the scientific literature for shared risk and overlapping disease mechanisms in the development of cancer and Parkinson disease (PD). This association has recently been highlighted with respect to melanoma and PD. Therefore, we review and discuss the literature concerning this unexplained link. A striking overlap is observed in the tyrosine and L-dopa biosynthetic pathways suggesting a common disease mechanism associated with these 2 heterogeneous disorders that warrants further investigation. Neurology (R) 2010;75:1653-1655

引用

页码：1653 / 1655

页数：3

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