Targeted transarterial oily chemoembolization for small foci of hepatocellular carcinoma using a unified helical CT and angiography system: Analysis of factors affecting local recurrence and survival rates

OBJECTIVE. We assessed the local recurrence rate after a single targeted transarterial oily chemoembolization for small hepatocellular carcinoma with the unified helical CT and angiography system and analyzed the factors affecting the local recurrence rate and survival rate with Coa proportional hazards model. MATERIALS AND METHODS. For 54 consecutive patients with 71 small hepatocellular carcinomas (less than or equal to5 cm) with no more than two associated lesions. targeted oily chemoembolization was performed with an emulsion of doxorubicin hydrochloride mixed with iodized oil or a suspension of zinostatin stimalamer followed by gelatin sponge particles. When local recurrence or a new lesion appeared. follow-up targeted oily chemoembolization was performed. RESULTS. For 52 of 71 lesions, the catheterization to a subsegmental or more distal feeding artery could be performed. Local recurrence was recognized in 33.2% at 1 year and 37.8% at 2 acid 3 years. The significant factors that affected local recurrence were tumor size (p = 0.005) and degree of deposition of iodized oil within the lesion (p = 0.049). The survival rates at 1, 2, and 3 years were 93.3%. 77.1%. and 77.1% respectively. The significant factors affecting survival rats were tumor thrombus in large vessels (p = 0.0001). appearing after the first chemoembolization, and maximum turner sire (p = 0.022), CONCLUSION. Single targeted transarterial oily chemoembolization with the unified helical CT and angiography system had a low local recurrence rate for small hepatocellular carcinoma. and follow-up embolization resulted in a good survival rate. Tumor sire along with degree of intratumoral iodized oil deposition and turner thrombus along with maximum tumor size were significant factors affecting local recurrence and survival rate. respectively.