CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance

被引:42
作者
Summers, Scott A. [1 ]
Goodpaster, Bret H. [2 ]
机构
[1] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
[2] Sanford Burnham Prebys Med Discovery Inst, Lake Nona, FL USA
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2016年 / 594卷 / 12期
关键词
SKELETAL-MUSCLE; METABOLIC SYNDROME; PLASMA CERAMIDES; SENSITIVITY; HUMANS; INHIBITION; EXERCISE; OBESITY; DIET; DIACYLGLYCEROL;
D O I
10.1113/JP271676
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:3167 / 3170
页数:4
相关论文
共 32 条
[1]   Ceramide content is increased in skeletal muscle from obese insulin-resistant humans [J].
Adams, JM ;
Pratipanawatr, T ;
Berria, R ;
Wang, E ;
DeFronzo, RA ;
Sullards, MC ;
Mandarino, LJ .
DIABETES, 2004, 53 (01) :25-31
[2]   Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes? [J].
Amati, Francesca ;
Dube, John J. ;
Alvarez-Carnero, Elvis ;
Edreira, Martin M. ;
Chomentowski, Peter ;
Coen, Paul M. ;
Switzer, Galen E. ;
Bickel, Perry E. ;
Stefanovic-Racic, Maja ;
Toledo, Frederico G. S. ;
Goodpaster, Bret H. .
DIABETES, 2011, 60 (10) :2588-2597
[3]   Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans [J].
Bergman, Bryan C. ;
Brozinick, Joseph T. ;
Strauss, Allison ;
Bacon, Samantha ;
Kerege, Anna ;
Bui, Hai Hoang ;
Sanders, Phil ;
Siddall, Parker ;
Kuo, Ming Shang ;
Perreault, Leigh .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 309 (04) :E398-E408
[4]   Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis [J].
Bikman, Benjamin T. ;
Guan, Yuguang ;
Shui, Guanghou ;
Siddique, M. Mobin ;
Holland, William L. ;
Kim, Ji Yun ;
Fabrias, Gemma ;
Wenk, Markus R. ;
Summers, Scott A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (21) :17426-17437
[5]   Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance [J].
Boon, James ;
Hoy, Andrew J. ;
Stark, Romana ;
Brown, Russell D. ;
Meex, Ruth C. ;
Henstridge, Darren C. ;
Schenk, Simon ;
Meikle, Peter J. ;
Horowitz, Jeffrey F. ;
Kingwell, Bronwyn A. ;
Bruce, Clinton R. ;
Watt, Matthew J. .
DIABETES, 2013, 62 (02) :401-410
[6]   Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet [J].
Brozinick, J. T. ;
Hawkins, E. ;
Bui, H. Hoang ;
Kuo, M-S ;
Tan, B. ;
Kievit, P. ;
Grove, K. .
INTERNATIONAL JOURNAL OF OBESITY, 2013, 37 (08) :1064-1070
[7]   Ceramides - Lipotoxic Inducers of Metabolic Disorders [J].
Chaurasia, Bhagirath ;
Summers, Scott A. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2015, 26 (10) :538-550
[8]   Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity [J].
Coen, P. M. ;
Hames, K. C. ;
Leachman, E. M. ;
DeLany, J. P. ;
Ritov, V. B. ;
Menshikova, E. V. ;
Dube, J. J. ;
Stefanovic-Racic, M. ;
Toledo, F. G. S. ;
Goodpaster, B. H. .
OBESITY, 2013, 21 (11) :2362-2371
[9]   Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery [J].
Coen, Paul M. ;
Menshikova, Elizabeth V. ;
Distefano, Giovanna ;
Zheng, Donghai ;
Tanner, Charles J. ;
Standley, Robert A. ;
Helbling, Nicole L. ;
Dubis, Gabriel S. ;
Ritov, Vladimir B. ;
Xie, Hui ;
Desimone, Marisa E. ;
Smith, Steven R. ;
Stefanovic-Racic, Maja ;
Toledo, Frederico G. S. ;
Houmard, Joseph A. ;
Goodpaster, Bret H. .
DIABETES, 2015, 64 (11) :3737-3750
[10]   Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content [J].
Coen, Paul M. ;
Dube, John J. ;
Amati, Francesca ;
Stefanovic-Racic, Maja ;
Ferrell, Robert E. ;
Toledo, Frederico G. S. ;
Goodpaster, Bret H. .
DIABETES, 2010, 59 (01) :80-88