Missing heritability and stochastic genome alterations

被引：35

作者：

Heng, Henry H. Q. ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 11期

关键词：

EVOLUTIONARY MECHANISM; CANCER; DISEASE; HETEROGENEITY;

D O I：

10.1038/nrg2809-c3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：812 / 812

页数：1

共 12 条

[1] VIEWPOINT Missing heritability and strategies for finding the underlying causes of complex disease [J].

Eichler, Evan E. ;

Flint, Jonathan ;

Gibson, Greg ;

Kong, Augustine ;

Leal, Suzanne M. ;

Moore, Jason H. ;

Nadeau, Joseph H. .

NATURE REVIEWS GENETICS, 2010, 11 (06) :446-450

[2] Cancer genome sequencing: the challenges ahead [J].

Heng, Henry H. Q. .

BIOESSAYS, 2007, 29 (08) :783-794

[3] Elimination of altered karyotypes by sexual reproduction preserves species identity [J].

Heng, Henry H. Q. .

GENOME, 2007, 50 (05) :517-524

[4] Stochastic cancer progression driven by non-clonal chromosome aberrations [J].

Heng, Henry H. Q. ;

Stevens, Joshua B. ;

Liu, Gou ;

Bremer, Steven W. ;

Ye, Karen J. ;

Reddy, Prem-Veer ;

Wu, Gen Sheng ;

Wang, Y. Alan ;

Tainsky, Michael A. ;

Ye, Christine J. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 208 (02) :461-472

[5] The Evolutionary Mechanism of Cancer [J].

Heng, Henry H. Q. ;

Stevens, Joshua B. ;

Bremer, Steven W. ;

Ye, Karen J. ;

Liu, Guo ;

Ye, Christine J. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 109 (06) :1072-1084

[6] The genome-centric concept: resynthesis of evolutionary theory [J].

Heng, Henry H. Q. .

BIOESSAYS, 2009, 31 (05) :512-525

[7] Chromosomal mosaicism goes global [J].

Iourov, Ivan Y. ;

Vorsanova, Svetlana G. ;

Yurov, Yuri B. .

MOLECULAR CYTOGENETICS, 2008, 1 (1)

[8] Genomic rearrangements and sporadic disease [J].

Lupski, James R. .

NATURE GENETICS, 2007, 39 (Suppl 7) :S43-S47

[9] Whole-Genome Sequencing in a Patient with Charcot-Marie-Tooth Neuropathy. [J].

Lupski, James R. ;

Reid, Jeffrey G. ;

Gonzaga-Jauregui, Claudia ;

Deiros, David Rio ;

Chen, David C. Y. ;

Nazareth, Lynne ;

Bainbridge, Matthew ;

Dinh, Huyen ;

Jing, Chyn ;

Wheeler, David A. ;

McGuire, Amy L. ;

Zhang, Feng ;

Stankiewicz, Pawel ;

Halperin, John J. ;

Yang, Chengyong ;

Gehman, Curtis ;

Guo, Danwei ;

Irikat, Rola K. ;

Tom, Warren ;

Fantin, Nick J. ;

Muzny, Donna M. ;

Gibbs, Richard A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (13) :1181-1191

[10] Genetic Heterogeneity in Human Disease [J].

McClellan, Jon ;

King, Mary-Claire .

CELL, 2010, 141 (02) :210-217

← 1 2 →