Prognostic value of lncRNAs in lung carcinoma: a meta-analysis

被引：5

作者：

Fan, Fan ^{[1
,2
]}

Zhu, Zhengqiu ^{[3
]}

Gao, Chao ^{[3
]}

Liu, Yun ^{[1
]}

Wang, Baoqing ^{[2
]}

Wang, Ziquan ^{[2
]}

Feng, Jifeng ^{[1
]}

机构：

[1] Nanjing Med Univ, Jiangsu Inst Canc Res, Jiangsu Canc Hosp, Dept Chemotherapy,Affiliated Canc Hosp, Nanjing 210009, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Affiliated Hosp 2, Dept Chemotherapy, Xuzhou 221000, Peoples R China

[3] Xuzhou Med Univ, Affiliated Hosp, Dept Chemotherapy, Xuzhou 221000, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 47期

基金：

中国国家自然科学基金;

关键词：

lncRNA; lung cancer; prognosis; NONCODING RNA HOTAIR; SQUAMOUS-CELL CANCER; POOR-PROGNOSIS; UP-REGULATION; PROLIFERATION; EXPRESSION; IDENTIFICATION; PROGRESSION; METASTASIS; INVASION;

D O I：

10.18632/oncotarget.21096

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many different long non-coding RNAs (lncRNAs) have been reported to be abnormally expressed in lung carcinoma and may thus serve as prognostic biomarkers for this disease. We conducted this meta-analysis, which included a total of 30 studies identified via searches of PubMed, Embase, Medline, and Web of Science and included 2912 patients from China (28), Germany (1), and Japan (1), to investigate the prognostic value of different lncRNAs in lung carcinoma. The results revealed that lncRNA transcription levels were significantly associated with overall survival in lung cancer patients (HR:1.46, 95% CI: 1.16-1.83, P = 0.000). However, lncRNA transcription levels were not associated with progression-free survival (PFS) (HR: 1.55, 95% CI: 0.50-4.80, P = 0.449). Further analysis showed that high lncRNA transcription levels were significantly associated with tumour-node-metastasis (TNM) stage (III/IV vs I/II: RR = 1.339, 95% CI: 1.046-1.716, P = 0.012), lymph node metastasis (positive vs negative: RR = 1.442, 95% CI: 1.103-1.885, P = 0.007), and distant metastasis (yes vs no: RR = 3.187,95% CI: 1.393-7.294, P = 0.006). Taken together, the results of our present meta-analysis revealed that lncRNAs may be useful prognostic markers for lung carcinoma and may also have value as biomarkers for TNM stage, lymph node metastasis and distant metastasis.

引用

页码：83292 / 83305

页数：14

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