Targeting an energy sensor to treat diabetes

被引：26

作者：

Hardie, D. Grahame ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Cell Signalling & Immunol, Dundee DD1 5EH, Scotland

来源：

SCIENCE | 2017年 / 357卷 / 6350期

基金：

英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; METFORMIN; MECHANISM; MICE;

D O I：

10.1126/science.aao1913

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：455 / 456

页数：2

共 14 条

[1] AMP-activated protein kinase in the heart - Role during health and disease [J].

Arad, Michael ;

Seidman, Christine E. ;

Seidman, J. G. .

CIRCULATION RESEARCH, 2007, 100 (04) :474-488

[2] Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice [J].

Cokorinos, Emily C. ;

Delmore, Jake ;

Reyes, Allan R. ;

Albuquerque, Bina ;

Kjobsted, Rasmus ;

Jorgensen, Nicolas O. ;

Tran, Jean-Luc ;

Jatkar, Aditi ;

Cialdea, Katherine ;

Esquejo, Ryan M. ;

Meissen, John ;

Calabrese, Matthew F. ;

Cordes, Jason ;

Moccia, Robert ;

Tess, David ;

Salatto, Christopher T. ;

Coskran, Timothy M. ;

Opsahl, Alan C. ;

Flynn, Declan ;

Blatnik, Matthew ;

Li, Wenlin ;

Kindt, Erick ;

Foretz, Marc ;

Viollet, Benoit ;

Ward, Jessica ;

Kurumbail, Ravi G. ;

Kalgutkar, Amit S. ;

Wojtaszewski, Jorgen F. P. ;

Cameron, Kimberly O. ;

Miller, Russell A. .

CELL METABOLISM, 2017, 25 (05) :1147-+

[3] Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome [J].

Cool, Barbara ;

Zinker, Bradley ;

Chiou, William ;

Kifle, Lemma ;

Cao, Ning ;

Perham, Matthew ;

Dickinson, Robert ;

Adler, Andrew ;

Gagne, Gerard ;

Iyengar, Rajesh ;

Zhao, Gang ;

Marsh, Kennan ;

Kym, Philip ;

Jung, Paul ;

Camp, Heidi S. ;

Frevert, Ernst .

CELL METABOLISM, 2006, 3 (06) :403-416

[4] Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state [J].

Foretz, Marc ;

Hebrard, Sophie ;

Leclerc, Jocelyne ;

Zarrinpashneh, Elham ;

Soty, Maud ;

Mithieux, Gilles ;

Sakamoto, Kei ;

Andreelli, Fabrizio ;

Viollet, Benoit .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (07) :2355-2369

[5] Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin [J].

Fullerton, Morgan D. ;

Galic, Sandra ;

Marcinko, Katarina ;

Sikkema, Sarah ;

Pulinilkunnil, Thomas ;

Chen, Zhi-Ping ;

O'Neill, Hayley M. ;

Ford, Rebecca J. ;

Palanivel, Rengasamy ;

O'Brien, Matthew ;

Hardie, D. Grahame ;

Macaulay, S. Lance ;

Schertzer, Jonathan D. ;

Dyck, Jason R. B. ;

van Denderen, Bryce J. ;

Kemp, Bruce E. ;

Steinberg, Gregory R. .

NATURE MEDICINE, 2013, 19 (12) :1649-1654

[6] Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase [J].

Goeransson, Olga ;

McBride, Andrew ;

Hawley, Simon A. ;

Ross, Fiona A. ;

Shpiro, Natalia ;

Foretz, Marc ;

Viollet, Benoit ;

Hardie, D. Grahame ;

Sakamoto, Kei .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (45) :32549-32560

[7] The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase [J].

Hawley, Simon A. ;

Fullerton, Morgan D. ;

Ross, Fiona A. ;

Schertzer, Jonathan D. ;

Chevtzoff, Cyrille ;

Walker, Katherine J. ;

Peggie, Mark W. ;

Zibrova, Darya ;

Green, Kevin A. ;

Mustard, Kirsty J. ;

Kemp, Bruce E. ;

Sakamoto, Kei ;

Steinberg, Gregory R. ;

Hardie, D. Grahame .

SCIENCE, 2012, 336 (6083) :918-922

[8] Choreography of AMPK activation [J].

Langendorf, Christopher G. ;

Kemp, Bruce E. .

CELL RESEARCH, 2015, 25 (01) :5-6

[9] Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy [J].

Myers, Robert W. ;

Guan, Hong-Ping ;

Ehrhart, Juliann ;

Petrov, Aleksandr ;

Prahalada, Srinivasa ;

Tozzo, Effie ;

Yang, Xiaodong ;

Kurtz, Marc M. ;

Trujillo, Maria ;

Trotter, Dinko Gonzalez ;

Feng, Danqing ;

Xu, Shiyao ;

Eiermann, George ;

Holahan, Marie A. ;

Rubins, Daniel ;

Conarello, Stacey ;

Niu, Xiaoda ;

Souza, Sandra C. ;

Miller, Corin ;

Liu, Jinqi ;

Lu, Ku ;

Feng, Wen ;

Li, Ying ;

Painter, Ronald E. ;

Milligan, James A. ;

He, Huaibing ;

Liu, Franklin ;

Ogawa, Aimie ;

Wisniewski, Douglas ;

Rohm, Rory J. ;

Wang, Liyang ;

Bunzel, Michelle ;

Qian, Ying ;

Zhu, Wei ;

Wang, Hongwu ;

Bennet, Bindu ;

Scheuch, Lisa LaFranco ;

Fernandez, Guillermo E. ;

Li, Cai ;

Klimas, Michael ;

Zhou, Gaochao ;

van Heek, Margaret ;

Biftu, Tesfaye ;

Weber, Ann ;

Kelley, David E. ;

Thornberry, Nancy ;

Erion, Mark D. ;

Kemp, Daniel M. ;

Sebhat, Iyassu K. .

SCIENCE, 2017, 357 (6350) :507-511

[10] AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours [J].

Ross, Fiona A. ;

MacKintosh, Carol ;

Hardie, D. Grahame .

FEBS JOURNAL, 2016, 283 (16) :2987-3001

← 1 2 →