Discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti-inflammatory activity in vivo zebrafish model

被引：23

作者：

Gui, Yu-Han ^{[1
,2
]}

Liu, Li ^{[1
]}

Wu, Wei ^{[1
]}

Zhang, Yun ^{[3
]}

Jia, Zhi-Li ^{[3
]}

Shi, Yong-Ping ^{[3
]}

Kong, Hao-Tian ^{[3
]}

Liu, Ke-Chun ^{[3
]}

Jiao, Wei-Hua ^{[1
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Ren Ji Hosp, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai 200127, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[3] Qilu Univ Technol, Inst Biol, Jinan 250103, Shandong, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 94卷

基金：

中国国家自然科学基金;

关键词：

Sesquiterpene quinone; Dysidea septosa; Anti-inflammatory; Zebrafish model; NF-KAPPA-B; A-C; MEROTERPENOIDS; HYDROQUINONE; AVAROL;

D O I：

10.1016/j.bioorg.2019.103435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3-10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-alpha and IL-6 generation with IC50 values of 9.15 mu M and 17.62 mu M, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.

引用

页数：7

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