Ligament and Tendon Repair through Regeneration Using Mesenchymal Stem Cells

被引:2
作者
Ramdass, Bharathi [1 ]
Koka, Prasad S. [1 ]
机构
[1] Haffkine Inst, Dept Virol & Immunol, Bombay 400012, Maharashtra, India
关键词
Mesenchymal stem cells; tendon and ligament; MARROW STROMAL CELLS; ADIPOGENIC DIFFERENTIATION; CALVARIAL DEFECTS; SIGNALING PATHWAY; BONE REGENERATION; NELL-1; EXPRESSION; ISCHEMIA; PROTEINS; ALPHA;
D O I
暂无
中图分类号
Q813 [细胞工程];
学科分类号
摘要
One of Nature's gifts to mankind is mesenchymal stem cells (MSC's). They are multipotent in nature and are present literally in every tissue. Since, they possess certain characteristics of stem cells such as self-renewal and differentiation they are known to be one of the key players in normal tissue homeostasis. This novel function of mesenchymal stem cells has been explored by scientists in the field of regenerative medicine. This review gives an insight of the various sources of mesenchymal stem cells available for tissue engineering with regard to tendon and ligament and the mechanism involved during regeneration.
引用
收藏
页码:84 / 88
页数:5
相关论文
共 65 条
  • [21] Gowri AM, 2013, INDIAN J MED RES, V137, P308
  • [22] Bone Marrow-Derived Mesenchymal Stem Cells Transduced With Scleraxis Improve Rotator Cuff Healing in a Rat Model
    Gulotta, Lawrence V.
    Kovacevic, David
    Packer, Jonathan D.
    Deng, Xiang Hua
    Rodeo, Scott A.
    [J]. AMERICAN JOURNAL OF SPORTS MEDICINE, 2011, 39 (06) : 1282 - 1289
  • [23] Stem Cells Genetically Modified With the Developmental Gene MT1-MMP Improve Regeneration of the Supraspinatus Tendon-to-Bone Insertion Site
    Gulotta, Lawrence V.
    Kovacevic, David
    Montgomery, Scott
    Ehteshami, John R.
    Packer, Jonathon D.
    Rodeo, Scott A.
    [J]. AMERICAN JOURNAL OF SPORTS MEDICINE, 2010, 38 (07) : 1429 - 1437
  • [24] Haynesworth SE, 1996, J CELL PHYSIOL, V166, P585, DOI 10.1002/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.3.CO
  • [25] 2-7
  • [26] Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
    Horwitz, EM
    Prockop, DJ
    Fitzpatrick, LA
    Koo, WWK
    Gordon, PL
    Neel, M
    Sussman, M
    Orchard, P
    Marx, JC
    Pyeritz, RE
    Brenner, MK
    [J]. NATURE MEDICINE, 1999, 5 (03) : 309 - 313
  • [27] Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression
    Hung, Shun-Pei
    Yang, Muh-Hwa
    Tseng, Kuo-Fung
    Lee, Oscar K.
    [J]. CELL TRANSPLANTATION, 2013, 22 (10) : 1869 - 1882
  • [28] Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation
    James, Aaron W.
    [J]. SCIENTIFICA, 2013, 2013
  • [29] Additive Effects of Sonic Hedgehog and Nell-1 Signaling in Osteogenic Versus Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
    James, Aaron W.
    Pang, Shen
    Askarinam, Asal
    Corselli, Mirko
    Zara, Janette N.
    Goyal, Raghav
    Chang, Le
    Pan, Angel
    Shen, Jia
    Yuan, Wei
    Stoker, David
    Zhang, Xinli
    Adams, John S.
    Ting, Kang
    Soo, Chia
    [J]. STEM CELLS AND DEVELOPMENT, 2012, 21 (12) : 2170 - 2178
  • [30] A new function of Nell-1 protein in repressing adipogenic differentiation
    James, Aaron W.
    Pan, Angel
    Chiang, Michael
    Zara, Janette N.
    Zhang, Xinli
    Ting, Kang
    Soo, Chia
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 411 (01) : 126 - 131