Exosomes: Current use and future applications

被引：116

作者：

Chung, Ill-Min ^{[1
]}

Rajakumar, Govindasamy ^{[1
]}

Venkidasamy, Baskar ^{[2
]}

Subramanian, Umadevi ^{[3
]}

Thiruvengadam, Muthu ^{[1
]}

机构：

[1] Konkuk Univ, Coll Sanghuh Life Sci, Dept Crop Sci, Seoul 05029, South Korea

[2] Bharathiar Univ, Dept Biotechnol, Coimbatore 641046, Tamil Nadu, India

[3] Tamil Nadu Vet & Anim Sci Univ TANUVAS, Translat Res Platform Vet Biol, Cent Univ Lab Bldg,Madhavaram Milk Colony, Chennai 600051, Tamil Nadu, India

来源：

CLINICA CHIMICA ACTA | 2020年 / 500卷

关键词：

Exosomes; Biomedical research; Drug delivery; Biomarkers; BLOOD-BRAIN-BARRIER; EXTRACELLULAR VESICLES; INDUCED OSTEONECROSIS; MEMBRANE-VESICLES; CELLS; MICROVESICLES; BIOMARKERS; BIOGENESIS; PATHWAY; IDENTIFICATION;

D O I：

10.1016/j.cca.2019.10.022

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Exosomes are endosomal-derived vesicles that play a critical role in cell-to-cell communication and are secreted in several biological fluids including serum, saliva, urine, ascites, and cerebro-spinal fluid amongst others. Exosomes are small (30-150 nm diameter) with a distinctive bilipid protein structure. They can carry and exchange various cargos between cells and are used as a non-invasive biomarker for several diseases. Exosomes are considered the best biomarkers for cancer diagnosis, owing to their unique characteristics. Here, we provide a review of the up-to-date applications of exosomes, derived from various sources, in the prognosis and diagnosis of several diseases including cancer, cardiovascular and regenerative diseases as well as, arthritis, neurological diseases, and diabetes mellitus. The role of exosomes and their applications in biomedical research and preclinical trials have also been briefly discussed.

引用

页码：226 / 232

页数：7

共 91 条

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