Measuring fetal adipose tissue using 3D water-fat magnetic resonance imaging: a feasibility study

被引：12
作者：
Giza, Stephanie A. [1 ]
Olmstead, Craig [2 ]
McCooeye, Daniel A. [1 ]
Miller, Michael R. [3 ,4 ]
Penava, Deborah A. [2 ,3 ,5 ]
Eastabrook, Genevieve D. [2 ,3 ,5 ]
McKenzie, Charles A. [1 ,3 ]
de Vrijer, Barbra [2 ,3 ,5 ]
机构：
[1] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada
[2] Western Univ, Schulich Sch Med & Dent, 800 Commissioners Rd E, London, ON, Canada
[3] Childrens Hlth Res Inst, London, ON, Canada
[4] Western Univ, Schulich Sch Med & Dent, Dept Pediat, London, ON, Canada
[5] Western Univ, Schulich Sch Med & Dent, Dept Obstet & Gynaecol, London, ON, Canada
来源：
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2020年 / 33卷 / 05期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Adipose tissue; development; fetus; magnetic resonance imaging; water-fat MRI; SUBCUTANEOUS FAT; BIRTH-WEIGHT; IN-UTERO; GROWTH; PREGNANCIES; PHENOTYPE; THICKNESS; HEALTHY; MRI;
D O I：
10.1080/14767058.2018.1506438
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Purpose: Analysis of fetal adipose tissue volumes may provide useful insight towards assessment of overall fetal health, especially in cases with abnormal fetal growth. Here, we assess whether fetal adipose tissue volume can be reliably measured using 3D water-fat MRI, using a quantitative assessment of the lipid content of tissues. Materials and methods: Seventeen women with singleton pregnancies underwent a fetal MRI and water-only and fat-only images were acquired (modified 2-point Dixon technique). Water and fat images were used to generate a fat signal fraction (fat/(water + fat)) from which subcutaneous adipose tissue was segmented along the fetal trunk. Inter-rater (three readers) and intrarater reliability was assessed using intraclass-correlation coefficients (ICC) for 10 image sets. Relationships between adipose tissue measurements and gestational age and estimated fetal weight percentiles were examined. Results: The ICC of the inter-rater reliability was 0.936 (p < .001), and the ICC of the intrarater reliability was 0.992 (p < .001). Strong positive correlations were found between adipose tissue measurements (lipid volume, lipid volume/total fetal volume, mean fat signal fraction) and gestational age. Conclusions: 3D water-fat MRI can reliably measure volume and quantify lipid content of fetal subcutaneous adipose tissues.
引用
收藏
页码：831 / 837
页数：7
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