Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment

被引：24

作者：

Chen, Yanyan ^{[1
]}

Huang, Mengxi ^{[1
]}

Liu, Xiaolong ^{[2
]}

Huang, Yadi ^{[3
]}

Liu, Chao ^{[4
]}

Zhu, Jialong ^{[3
]}

Fu, Gongbo ^{[1
,3
]}

Lei, Zengjie ^{[1
,3
]}

Chu, Xiaoyuan ^{[1
,3
,4
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Med Sch, Dept Med Oncol, Nanjing, Peoples R China

[2] Nanjing Med Univ, Jinling Hosp, Dept Cardiothorac Surg, Nanjing, Peoples R China

[3] Southern Med Univ, Sch Clin Med 1, Jinling Hosp, Dept Med Oncol, Nanjing, Peoples R China

[4] Nanjing Med Univ, Jinling Hosp, Dept Med Oncol, Nanjing, Peoples R China

来源：

CELL DEATH & DISEASE | 2021年 / 12卷 / 08期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

CRYO-EM STRUCTURE; ANTISENSE OLIGONUCLEOTIDES; COLON CANCERS; IN-VIVO; PHASE-I; ISOFORM; EXPRESSION; PROTEIN; SPLICEOSOME; GROWTH;

D O I：

10.1038/s41419-021-04031-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed.

引用

页数：16

共 138 条

[91] Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab [J].

Pentheroudakis, George ;

Mavroeidis, Leonidas ;

Papadopoulou, Kyriaki ;

Koliou, Georgia-Angeliki ;

Bamia, Christina ;

Chatzopoulos, Kyriakos ;

Samantas, Epaminontas ;

Mauri, Davide ;

Efstratiou, Ioannis ;

Pectasides, Dimitrios ;

Makatsoris, Thomas ;

Bafaloukos, Dimitrios ;

Papakostas, Pavlos ;

Papatsibas, George ;

Bombolaki, Iliada ;

Chrisafi, Sofia ;

Kourea, Helen P. ;

Petraki, Kalliopi ;

Kafiri, Georgia ;

Fountzilas, George ;

Kotoula, Vassiliki .

CLINICAL COLORECTAL CANCER, 2019, 18 (04) :E370-E384

[92] Structure of a pre-catalytic spliceosome [J].

Plaschka, Clemens ;

Lin, Pei-Chun ;

Nagai, Kiyoshi .

NATURE, 2017, 546 (7660) :617-+

[93] Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation [J].

Prabhu, Varun V. ;

Hong, Bo ;

Allen, Joshua E. ;

Zhang, Shengliang ;

Lulla, Amriti R. ;

Dicker, David T. ;

El-Deiry, Wafik S. .

CANCER RESEARCH, 2016, 76 (07) :1989-1999

[94] Confirmation of damaging effect of MSH2 c.2634+1G>C mutation on splicing, its classification and implications for counseling [J].

Rakobradovic, Jelena ;

Krivokuka, Ana ;

Jovandic, Stevo ;

Kesic, Vesna ;

Brankovic-Magic, Mirjana .

CANCER GENETICS, 2019, 239 :1-7

[95] Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors [J].

Rangwala, Fatima ;

Bendell, Johanna C. ;

Kozloff, Mark F. ;

Arrowood, Christy C. ;

Dellinger, Andrew ;

Meadows, Jennifer ;

Tourt-Uhlig, Sandra ;

Murphy, Jennifer ;

Meadows, Kellen L. ;

Starr, Aijing ;

Broderick, Samuel ;

Brady, John C. ;

Cushman, Stephanie M. ;

Morse, Michael A. ;

Uronis, Hope E. ;

Hsu, S. David ;

Zafar, S. Yousuf ;

Wallace, James ;

Starodub, Alexander N. ;

Strickler, John H. ;

Pang, Herbert ;

Nixon, Andrew B. ;

Hurwitz, Herbert I. .

INVESTIGATIONAL NEW DRUGS, 2014, 32 (04) :700-709

[96] The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer [J].

Rey, C. ;

Faustin, B. ;

Mahouche, I. ;

Ruggieri, R. ;

Brulard, C. ;

Ichas, F. ;

Soubeyran, I. ;

Lartigue, L. ;

De Giorgi, F. .

ONCOGENE, 2016, 35 (24) :3190-3200

[97] HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition [J].

Sakuma, Keiichiro ;

Sasaki, Eiichi ;

Kimura, Kenya ;

Komori, Koji ;

Shimizu, Yasuhiro ;

Yatabe, Yasushi ;

Aoki, Masahiro .

GUT, 2018, 67 (06) :1103-1111

[98] CD44 functions in Wnt signaling by regulating LRP6 localization and activation [J].

Schmitt, M. ;

Metzger, M. ;

Gradl, D. ;

Davidson, G. ;

Orian-Rousseau, V. .

CELL DEATH AND DIFFERENTIATION, 2015, 22 (04) :677-689

[99] RNA mis-splicing in disease [J].

Scotti, Marina M. ;

Swanson, Maurice S. .

NATURE REVIEWS GENETICS, 2016, 17 (01) :19-32

[100] Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes [J].

Shirts, Brian H. ;

Konnick, Eric Q. ;

Upham, Sarah ;

Walsh, Tom ;

Ranola, John Michael O. ;

Jacobson, Angela L. ;

King, Mary-Claire ;

Pearlman, Rachel ;

Hampel, Heather ;

Pritchard, Colin C. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 103 (01) :19-29

← 5 6 7 8 9 10 11 12 13 14 →