Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2

被引：113
作者：
Watanabe, Rie [1 ]
Nakamura, Hajime [2 ]
Masutani, Hiroshi [1 ]
Yodoi, Junji [1 ]
机构：
[1] Inst Virus Res, Lab Infect & Prevent, Dept Biol Responses, Sakyo Ku, Kyoto 6068507, Japan
[2] Tazuke Kofukai Med Res Inst Kitano Hosp, Dept Prevent Med, Kita Ku, Osaka 5308480, Japan
来源：
PHARMACOLOGY & THERAPEUTICS | 2010年 / 127卷 / 03期
关键词：
Thioredoxin 1 (Trx 1); Thioredoxin-binding protein-2 (TBP-2); Metabolic disorder; Cancer; Inflammation; UP-REGULATED PROTEIN-1; T-CELL LEUKEMIA; FAMILIAL COMBINED HYPERLIPIDEMIA; CARBOHYDRATE RESPONSE ELEMENT; ISCHEMIA-REPERFUSION INJURY; PANCREATIC BETA-CELLS; INHIBITORY FACTOR MIF; INTERACTING PROTEIN; OXIDATIVE STRESS; TRANSGENIC MICE;
D O I：
10.1016/j.pharmthera.2010.04.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Thioredoxin 1 (Trx 1) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- that is ubiquitously present in the human body. Trx 1 is a defensive protein induced by various stresses and has anti-oxidative, anti-apoptotic and anti-inflammatory effects. The anti-oxidative effect of Trx 1 is mediated by the dithiol-disulfide exchange in the active site. Trx 1 is able to interact with certain molecules, one of which is thioredoxin-binding protein-2 (TBP-2)/Vitamin D3 upregulated protein 1 (VDUP1)/thioredoxin interacting protein (TXNIP). TBP-2 was originally identified as a negative regulator of Trx 1 and acts as a cell growth suppressor and a regulator in lipid/glucose metabolism. Trx 1 and TBP-2 play crucial roles in pathophysiological mechanisms in metabolic disorders, cancer and inflammation. Here we discuss pharmacological aspects of Trx 1 and TBP-2 in these diseases and propose potential therapeutic approaches for intractable oxidative stress-related disorders. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：261 / 270
页数：10
相关论文
共 133 条
  • [1] Thioredoxin-Binding Protein-2 Deficiency Enhances Methionine-Choline Deficient Diet-Induced Hepatic Steatosis But Inhibits Steatohepatitis in Mice
    Ahsan, Md. Kaimul
    Okuyama, Hiroaki
    Hoshino, Yuma
    Oka, Shin-Ichi
    Masutani, Hiroshi
    Yodoi, Junji
    Nakamura, Hajime
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2009, 11 (10) : 2573 - 2584
  • [2] Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2
    Ahsan, MK
    Masutani, H
    Yamaguchi, Y
    Kim, YC
    Nosaka, K
    Matsuoka, M
    Nishinaka, Y
    Maeda, M
    Yodoi, J
    [J]. ONCOGENE, 2006, 25 (15) : 2181 - 2191
  • [3] Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt
    Ahsan, MK
    Nakamura, H
    Tanito, M
    Yamada, K
    Utsumi, H
    Yodoi, J
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (12) : 1549 - 1559
  • [4] Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells
    Bai, J
    Nakamura, H
    Kwon, YW
    Hattori, I
    Yamaguchi, Y
    Kim, YC
    Kondo, N
    Oka, S
    Ueda, S
    Masutani, H
    Yodoi, J
    [J]. JOURNAL OF NEUROSCIENCE, 2003, 23 (02) : 503 - 509
  • [5] The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
    Baker, AF
    Dragovich, T
    Tate, WR
    Ramanathan, RK
    Roe, D
    Hsu, CH
    Kirkpatrick, DL
    Powis, G
    [J]. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2006, 147 (02): : 83 - 90
  • [6] Berggren M, 1996, ANTICANCER RES, V16, P3459
  • [7] Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells
    Bertini, R
    Howard, OMZ
    Dong, HF
    Oppenheim, JJ
    Bizzarri, C
    Sergi, R
    Caselli, G
    Pagliei, S
    Romines, B
    Wilshire, JA
    Mengozzi, M
    Nakamura, H
    Yodoi, J
    Pekkari, K
    Gurunath, R
    Holmgren, A
    Herzenberg, LA
    Herzenberg, LA
    Ghezzi, P
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) : 1783 - 1789
  • [8] Positional cloning of the combined hyperlipidemia gene Hyplip1
    Bodnar, JS
    Chatterjee, A
    Castellani, LW
    Ross, DA
    Ohmen, J
    Cavalcoli, J
    Wu, CY
    Dains, KM
    Catanese, J
    Chu, M
    Sheth, SS
    Charugundla, K
    Demant, P
    West, DB
    de Jong, P
    Lusis, AJ
    [J]. NATURE GENETICS, 2002, 30 (01) : 110 - 116
  • [9] Thioredoxin: friend or foe in human disease?
    Burke-Gaffney, A
    Callister, MEJ
    Nakamura, H
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (08) : 398 - 404
  • [10] The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
    Butler, LM
    Zhou, XB
    Xu, WS
    Scher, HI
    Rifkind, RA
    Marks, PA
    Richon, VM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11700 - 11705
12345678910