Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2

被引：119

作者：

Watanabe, Rie ^{[1
]}

Nakamura, Hajime ^{[2
]}

Masutani, Hiroshi ^{[1
]}

Yodoi, Junji ^{[1
]}

机构：

[1] Inst Virus Res, Lab Infect & Prevent, Dept Biol Responses, Sakyo Ku, Kyoto 6068507, Japan

[2] Tazuke Kofukai Med Res Inst Kitano Hosp, Dept Prevent Med, Kita Ku, Osaka 5308480, Japan

来源：

PHARMACOLOGY & THERAPEUTICS | 2010年 / 127卷 / 03期

关键词：

Thioredoxin 1 (Trx 1); Thioredoxin-binding protein-2 (TBP-2); Metabolic disorder; Cancer; Inflammation; UP-REGULATED PROTEIN-1; T-CELL LEUKEMIA; FAMILIAL COMBINED HYPERLIPIDEMIA; CARBOHYDRATE RESPONSE ELEMENT; ISCHEMIA-REPERFUSION INJURY; PANCREATIC BETA-CELLS; INHIBITORY FACTOR MIF; INTERACTING PROTEIN; OXIDATIVE STRESS; TRANSGENIC MICE;

D O I：

10.1016/j.pharmthera.2010.04.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thioredoxin 1 (Trx 1) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- that is ubiquitously present in the human body. Trx 1 is a defensive protein induced by various stresses and has anti-oxidative, anti-apoptotic and anti-inflammatory effects. The anti-oxidative effect of Trx 1 is mediated by the dithiol-disulfide exchange in the active site. Trx 1 is able to interact with certain molecules, one of which is thioredoxin-binding protein-2 (TBP-2)/Vitamin D3 upregulated protein 1 (VDUP1)/thioredoxin interacting protein (TXNIP). TBP-2 was originally identified as a negative regulator of Trx 1 and acts as a cell growth suppressor and a regulator in lipid/glucose metabolism. Trx 1 and TBP-2 play crucial roles in pathophysiological mechanisms in metabolic disorders, cancer and inflammation. Here we discuss pharmacological aspects of Trx 1 and TBP-2 in these diseases and propose potential therapeutic approaches for intractable oxidative stress-related disorders. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：261 / 270

页数：10

共 133 条

[1] Thioredoxin-Binding Protein-2 Deficiency Enhances Methionine-Choline Deficient Diet-Induced Hepatic Steatosis But Inhibits Steatohepatitis in Mice [J].

Ahsan, Md. Kaimul ;

Okuyama, Hiroaki ;

Hoshino, Yuma ;

Oka, Shin-Ichi ;

Masutani, Hiroshi ;

Yodoi, Junji ;

Nakamura, Hajime .

ANTIOXIDANTS & REDOX SIGNALING, 2009, 11 (10) :2573-2584

[2] Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2 [J].

Ahsan, MK ;

Masutani, H ;

Yamaguchi, Y ;

Kim, YC ;

Nosaka, K ;

Matsuoka, M ;

Nishinaka, Y ;

Maeda, M ;

Yodoi, J .

ONCOGENE, 2006, 25 (15) :2181-2191

[3] Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt [J].

Ahsan, MK ;

Nakamura, H ;

Tanito, M ;

Yamada, K ;

Utsumi, H ;

Yodoi, J .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (12) :1549-1559

[4] Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells [J].

Bai, J ;

Nakamura, H ;

Kwon, YW ;

Hattori, I ;

Yamaguchi, Y ;

Kim, YC ;

Kondo, N ;

Oka, S ;

Ueda, S ;

Masutani, H ;

Yodoi, J .

JOURNAL OF NEUROSCIENCE, 2003, 23 (02) :503-509

[5] The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma [J].

Baker, AF ;

Dragovich, T ;

Tate, WR ;

Ramanathan, RK ;

Roe, D ;

Hsu, CH ;

Kirkpatrick, DL ;

Powis, G .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2006, 147 (02) :83-90

[6]

Berggren M, 1996, ANTICANCER RES, V16, P3459

[7] Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells [J].

Bertini, R ;

Howard, OMZ ;

Dong, HF ;

Oppenheim, JJ ;

Bizzarri, C ;

Sergi, R ;

Caselli, G ;

Pagliei, S ;

Romines, B ;

Wilshire, JA ;

Mengozzi, M ;

Nakamura, H ;

Yodoi, J ;

Pekkari, K ;

Gurunath, R ;

Holmgren, A ;

Herzenberg, LA ;

Ghezzi, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1783-1789

[8] Positional cloning of the combined hyperlipidemia gene Hyplip1 [J].

Bodnar, JS ;

Chatterjee, A ;

Castellani, LW ;

Ross, DA ;

Ohmen, J ;

Cavalcoli, J ;

Wu, CY ;

Dains, KM ;

Catanese, J ;

Chu, M ;

Sheth, SS ;

Charugundla, K ;

Demant, P ;

West, DB ;

de Jong, P ;

Lusis, AJ .

NATURE GENETICS, 2002, 30 (01) :110-116

[9] Thioredoxin: friend or foe in human disease? [J].

Burke-Gaffney, A ;

Callister, MEJ ;

Nakamura, H .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (08) :398-404

[10] The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin [J].

Butler, LM ;

Zhou, XB ;

Xu, WS ;

Scher, HI ;

Rifkind, RA ;

Marks, PA ;

Richon, VM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11700-11705

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