Hematopoietic stem cell transplantation in sickle cell disease

被引：34

作者：

Vermylen, C ^{[1
]}

机构：

[1] Catholic Univ Louvain, Clin Univ St Luc, Dept Pediat Hematol, B-1200 Brussels, Belgium

来源：

BLOOD REVIEWS | 2003年 / 17卷 / 03期

关键词：

sickle cell anemia; stem cell transplantation;

D O I：

10.1016/S0268-960X(03)00006-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the first report of a young girl affected by sickle cell anemia, treated successfully by bone marrow transplantation (BMT) for acute myeloid leukemia, more than 200 patients have been transplanted worldwide for sickle cell anemia. The disease-free survival (DFS) is good (80-85% in several series), eventhough many children who received allografts had already significant sickle-related complications. The best results are obtained in young children who have HLA-identical sibling donors and are transplanted early in the course of the disease (DFS: 93%). Future directions in the field of stem cell transplantation of sickle cell anemia include (1) the establishment of new protocols with less toxicity, but still effective, (2) adapted conditioning regimen for adult patients, and (3) new sources of stem cells for broader application: umbilical cord blood and volunteer unrelated donors. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：163 / 166

页数：4

共 35 条

[1] Fatal sickle cell crisis after granulocyte colony-stimulating factor administration [J].

Adler, BK ;

Salzman, DE ;

Carabasi, MH ;

Vaughan, WP ;

Reddy, VVB ;

Prchal, JT .

BLOOD, 2001, 97 (10) :3313-3314

[2]

Bernaudin F, 1997, BONE MARROW TRANSPL, V19, P112

[3]

BorgnaPignatti C, 1996, BONE MARROW TRANSPL, V18, P235

[4] EFFECT OF HYDROXYUREA ON THE FREQUENCY OF PAINFUL CRISES IN SICKLE-CELL-ANEMIA [J].

CHARACHE, S ;

TERRIN, ML ;

MOORE, RD ;

DOVER, GJ ;

BARTON, FB ;

ECKERT, SV ;

MCMAHON, RP ;

BONDS, DR ;

ORRINGER, E ;

JONES, S ;

STRAYHORN, D ;

ROSSE, W ;

PHILLIPS, G ;

PEACE, D ;

JOHNSONTELFAIR, A ;

MILNER, P ;

KUTLAR, A ;

TRACY, A ;

BALLAS, SK ;

ALLEN, GE ;

MOSHANG, J ;

SCOTT, B ;

STEINBERG, M ;

ANDERSON, A ;

SABAHI, V ;

PEGELOW, C ;

TEMPLE, D ;

CASE, E ;

HARRELL, R ;

CHILDERIE, S ;

EMBURY, S ;

SCHMIDT, B ;

DAVIES, D ;

KOSHY, M ;

TALISCHYZAHED, N ;

DORN, L ;

PENDARVIS, G ;

MCGEE, M ;

TELFER, M ;

DAVIS, A ;

CASTRO, O ;

FINKE, H ;

PERLIN, E ;

SITEMAN, J ;

GASCON, P ;

DIPAOLO, P ;

GARGIULO, S ;

ECKMAN, J ;

BAILEY, JH ;

PLATT, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1317-1322

[5] Five years of experience with hydroxyurea in children and young adults with sickle cell disease [J].

Ferster, A ;

Tahriri, P ;

Vermylen, C ;

Sturbois, G ;

Corazza, F ;

Fondu, P ;

Devalck, C ;

Dresse, MF ;

Feremans, W ;

Hunninck, K ;

Toppet, M ;

Philippet, P ;

Van Geet, C ;

Sariban, E .

BLOOD, 2001, 97 (11) :3628-3632

[6]

FERSTER A, 1993, BLOOD, V81, P1102

[7] Bone marrow transplantation from alternative donors for thalassemia: HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplants [J].

Gaziev, D ;

Galimberti, M ;

Lucarelli, G ;

Polchi, P ;

Giardini, C ;

Angelucci, E ;

Baronciani, D ;

Sodani, P ;

Erer, B ;

De Biagi, M ;

Andreani, M ;

Agostinelli, F ;

Donati, M ;

Nesci, S ;

Talevi, N .

BONE MARROW TRANSPLANTATION, 2000, 25 (08) :815-821

[8] Megadose transplantation of purified peripheral blood CD34+progenitor cells from HLA-mismatched parental donors in children [J].

Handgretinger, R ;

Klingebiel, T ;

Lang, P ;

Schumm, M ;

Neu, S ;

Geiselhart, A ;

Bader, P ;

Schlegel, PG ;

Greil, J ;

Stachel, D ;

Herzog, RJ ;

Niethammer, D .

BONE MARROW TRANSPLANTATION, 2001, 27 (08) :777-783

[9] Bone marrow transplantation in sickle cell anemia [J].

Hoppe, CC ;

Walters, MC .

CURRENT OPINION IN ONCOLOGY, 2001, 13 (02) :85-90

[10]

HORAN J, 2002, HEMATOPOIETIC STEM C

← 1 2 3 4 →