Mononucleating nicotinohydazone complexes with VO2+, Cu2+, and Ni2+ ions. Characteristic, catalytic, and biological assessments

被引：19
作者：
Adam, Mohamed Shaker S. [1 ,2 ]
Makhlouf, M. M. [3 ]
Ullah, Farman [4 ]
El-Hady, Omar M. [2 ]
机构：
[1] King Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hasa 31982, Saudi Arabia
[2] Sohag Univ, Fac Sci, Chem Dept, Sohag 82534, Egypt
[3] Taif Univ, Ranyah Univ Coll, Dept Sci & Technol, POB 11099, At Taif 21944, Saudi Arabia
[4] Winnipeg Univ, Dept Chem, 515 Portage Ave, Winnipeg, MB R3B 2E9, Canada
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 334卷
关键词：
Phenylhydrazone; Epoxidation; 1,2-cyclooctene; CtDNA interaction; Antimicrobial; Antioxidant and anticancer; SCHIFF-BASE COMPLEXES; TRANSITION-METAL-COMPLEXES; COPPER(II) COMPLEXES; MOLECULAR DOCKING; OXIDATION; LIGANDS; CO(II); BINDING; NI(II); CU(II);
D O I：
10.1016/j.molliq.2021.116001
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Three novel mononuclear complexes of Ni2+, Cu2+, and VO2+ ions (NiLnBu, CuLnBu, and VOLnBu, respectively) were synthesized by the chelation of a di-basic tridentate nicotinohydazone ligand (H(2)LnBu) with M2+ ions in 1 : 1 M ratios. The ligand and its M-pincer chelates were identified and characterized using various spectroscopic tools included NMR, IR, UV-Vis. and EI-Mass spectra, beside, EI elemental analyses, and thermogravimetric analyses. The catalytic potential of NiLnBu, CuLnBu, and VOLnBu was investigated in 1,2-cyclooctene epoxidation using H2O2, as an efficient oxidant. Various parameters, including solvent, temperature, catalyst loading, and oxidant were investigated to identify the optimized reaction conditions. The central metal ion in their M-chelate catalysts revealed variation in the catalytic performance. The high valent metal ion (V4+) catalyst (VOLnBu) exhibited slightly better catalytic potential (96% yield) over the low valent metal ions (Ni2+ and Cu2+) complex catalysts (NiLnBu 91% yield and CuLnBu 93% yield, respectively). In addition to, the biological potential of free ligand H(2)LnBu and its complexes were examined in the ctDNA interaction process via UV-Vis. spectroscopy and viscosity measurements with the aid of distinguished docking studies. The obtained results showed that M-chelates possess effective biological activities with DNA, including the antimicrobial, antioxidant, and anticancer effects against different biological targets. (C) 2021 Elsevier B.V. All rights reserved.
引用
收藏
页数：17
相关论文
共 92 条
  • [1] Synthesis, theoretical investigations, biocidal screening, DNA binding, in vitro cytotoxicity and molecular docking of novel Cu (II), Pd (II) and Ag (I) complexes of chlorobenzylidene Schiff base: Promising antibiotic and anticancer agents
    Abdel-Rahman, Laila H.
    Adam, Mohamed Shaker S.
    Abu-Dief, Ahmed M.
    Moustafa, H.
    Basha, Maram T.
    Aboraia, Ahmed S.
    Al-Farhan, Badriah Saad
    Ahmed, Hanan El-Sayed
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (12)
  • [2] Three novel Ni(II), VO(II) and Cr(III) mononuclear complexes encompassing potentially tridentate imine ligand: Synthesis, structural characterization, DNA interaction, antimicrobial evaluation and anticancer activity
    Abdel-Rahman, Laila H.
    Abu-Dief, Ahmed M.
    Basha, Maram
    Abdel-Mawgoud, Azza A. Hassan
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2017, 31 (11)
  • [3] Some New Nano-sized Mononuclear Cu(II) Schiff Base Complexes: Design, Characterization, Molecular Modeling and Catalytic Potentials in Benzyl Alcohol Oxidation
    Abdel-Rahman, Laila H.
    Abu-Dief, Ahmed M.
    Adam, Mohamed Shaker S.
    Hamdan, Samar Kamel
    [J]. CATALYSIS LETTERS, 2016, 146 (08) : 1373 - 1396
  • [4] Targeting ctDNA binding and elaborated in-vitro assessments concerning novel Schiff base complexes: Synthesis, characterization, DFT and detailed in-silico confirmation
    Abu-Dief, Ahmed M.
    El-Metwaly, Nashwa M.
    Alzahrani, Seraj Omar
    Bawazeer, Afrah M.
    Shaaban, Saad
    Adam, Mohamed Shaker S.
    [J]. JOURNAL OF MOLECULAR LIQUIDS, 2021, 322 (322)
  • [5] Synthesis, Characterization, and Application of Vanadium-Salan Complexes in Oxygen Transfer Reactions
    Adaeo, Pedro
    Pessoa, Joao Costa
    Henriques, Rul T.
    Kuznetsov, Maxim L.
    Avecilla, Fernando
    Maurya, Mannar R.
    Kumar, Umesh
    Correia, Isabel
    [J]. INORGANIC CHEMISTRY, 2009, 48 (08) : 3542 - 3561
  • [6] Catalytic and biological reactivities of mononuclear copper (II) and vanadyl (II) complexes of naphthalenylimino-phenolate sodium sulfonate
    Adam, Mohamed Shaker S.
    Makhlouf, M. M.
    Ullah, Farman
    Mohamad, Ahmad Desoky M.
    [J]. JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2021, 118 : 12 - 28
  • [7] Bis-dioxomolybdenum (VI) oxalyldihydrazone complexes: Synthesis, characterization, DFT studies, catalytic epoxidation potential, molecular modeling and biological evaluations
    Adam, Mohamed Shaker S.
    Ahmed, Mohamed S. Mohamed
    El-Hady, Omar M.
    Shaaban, Saad
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (05)
  • [8] Biological and catalytic potential of sustainable low and high valent metal-Schiff base sulfonate salicylidene pincer complexes
    Adam, Mohamed Shaker S.
    El-Hady, Omar M.
    Ullah, Farman
    [J]. RSC ADVANCES, 2019, 9 (59) : 34311 - 34329
  • [9] Catalytic comparison of various polar Zn(II)-Schiff base complexes and VO(II)-Schiff base complexes in (ep)oxidation processes of 1,2-cyclohexene and cyclohexane
    Adam, Mohamed Shaker S.
    Al-Omair, Mohammed A.
    Ullah, Farman
    [J]. RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (09) : 4653 - 4675
  • [10] Catalytic (ep)oxidation and corrosion inhibition potentials of CuII and CoII pyridinylimino phenolate complexes
    Adam, Mohamed Shaker S.
    Mohamad, Ahmad Desoky M.
    [J]. POLYHEDRON, 2018, 151 : 118 - 130
12345678910