Synthesis, characterization and in vitro antibacterial evaluation of 1-(7,7-dimethyl-2-morpholino-5,6,7,8-tetrahydroquinazolin-4-yl)piperidine-4-carboxamide derivatives

被引：4
作者：
Selvakumar, Balaraman [1 ,2 ]
Elango, Kuppanagounder P. [2 ]
机构：
[1] Anthem Biosci Private Ltd, Bangalore 560099, Karnataka, India
[2] Deemed Univ, Dept Chem, Gandhigram Rural Inst, Gandhigram 624302, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 10期
关键词：
Synthesis; Characterization; Tetrahydroquinazoline; Piperazine; Morpholine; Antibacterial; BIOLOGICAL-ACTIVITY; MOLECULAR DOCKING; INHIBITORS; PYRIMIDINE;
D O I：
10.1007/s11164-017-2945-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of six novel 1-(7,7-dimethyl-2-morpholino-5,6,7,8-tetrahydroquinazolin-4-yl)piperidine-4-carboxamide derivatives has been synthesized and characterized using various spectral techniques (H-1 and C-13 NMR, LCMS, IR). The antibacterial activities of these compounds have been screened against nine different Gram-positive and Gram-negative bacterial strains. The results show that quinazoline derivatives containing thiazole ring 2a and 2b exhibit good antibacterial activity amongst the compounds under investigation.
引用
收藏
页码：5535 / 5546
页数：12
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