A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals

被引：28

作者：

Guan, Mirong ^{[1
,2
]}

Li, Jie ^{[1
,2
]}

Jia, Qingyan ^{[3
]}

Ge, Jiechao ^{[3
]}

Chen, Daiqin ^{[1
,2
]}

Zhou, Yue ^{[1
,2
]}

Wang, Pengfei ^{[3
]}

Zou, Toujun ^{[1
,2
]}

Zhen, Mingming ^{[1
,2
]}

Wang, Chunru ^{[1
,2
]}

Shu, Chunying ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China

[2] Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[3] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, TIPC, Beijing 100190, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2016年 / 5卷 / 17期

基金：

中国国家自然科学基金;

关键词：

clearance; imaging; nanocarbon; photodynamic therapy; theranostics; IN-VIVO BIODISTRIBUTION; GRAPHENE QUANTUM DOTS; THERAPEUTIC APPLICATIONS; POLYMERIC NANOPARTICLES; NANODOTS SYNTHESIS; BLOOD-CIRCULATION; SURFACE-CHEMISTRY; CANCER-DIAGNOSIS; DRUG-DELIVERY; NANOMATERIALS;

D O I：

10.1002/adhm.201600402

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanocarbons such as carbon nanotubes, graphene derivatives, and carbon nanohorns have illustrated their potential uses as cancer theranostics owing to their intrinsic fluorescence or NIR absorbance as well as superior cargo loading capacity. However, some problems still need to be addressed, such as the fates and long-term toxicology of different nanocarbons in vivo and the improvement of their performance in various biomedical imaging-guided cancer therapy systems. Herein, a versatile and clearable nanocarbon theranostic based on carbon dots (CDs) and gadolinium metallofullerene nanocrystals (GFNCs) is first developed, in which GFNCs enhance the tumor accumulation of CDs, and CDs enhance the relaxivity of GFNCs, leading to an efficient multimodal imaging-guided photodynamic therapy in vivo without obvious long-term toxicity. Furthermore, biochemical analysis reveals that the novel nanotheranostic can harmlessly eliminate from the body in a reasonable period of time after exerting diagnostic and therapeutic function.

引用

页码：2283 / 2294

页数：12

共 127 条

[71] Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives [J].