Characterization of thermo-sensitive hydrogels based on poly(N-isopropylacrylamide)/hyaluronic acid

被引：44

作者：

Coronado, Ramon ^{[1
]}

Pekerar, Sara ^{[2
]}

Lorenzo, Arnaldo T. ^{[3
]}

Sabino, Marcos A. ^{[1
]}

机构：

[1] Univ Simon Bolivar, Dept Chem, Grp B5IDA, Caracas 1080, Venezuela

[2] IVIC, Venezuelan Inst Sci Res, Ctr Chem, Estado Miranda, Venezuela

[3] Univ Simon Bolivar, Dept Mat Sci, USB Polymer Grp, Caracas 1080, Venezuela

来源：

POLYMER BULLETIN | 2011年 / 67卷 / 01期

关键词：

Poly-NIPA; Hyaluronic acid; Thermo-sensitive; Interpenetrating polymer network; Injectable hydrogel; HYALURONIC-ACID; PHASE-TRANSITIONS; SWELLING BEHAVIOR; COPOLYMERS; DEGRADATION; GELATIN; RELEASE;

D O I：

10.1007/s00289-010-0407-6

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, an hydrogel was synthesized from the monomer N-isopropylacrylamide (NIPA), generating the poly(N-isopropylacrylamide) (PNIPA) and other formulations were synthesized in the presence of 1, 2, and 3% hyaluronic acid (HA) for obtain an interpenetrating polymer network. For all the obtained hydrogels, the thermo-sensitive response was studied since the lower critical solution temperature (LCST) and was analyzed by differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and oscillatory rheology at constant frequency as a function of temperature. The LCST transition temperature (Tt onset) was found between 34.4 and 35.5 A degrees C. By scanning electron microscopy (SEM) PNIPA-HA formulations showed a porous morphology. The applicability of the hydrogels as injectable and non-toxic materials was verified, respectively, by rheology results and by cytotoxicity studies through an in vitro test of cell hemolysis on blood agar.

引用

页码：101 / 124

页数：24

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