The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment

被引:27
作者
Spitzweg, C. [1 ,2 ]
Nelson, P. J. [1 ]
Wagner, E. [3 ,4 ]
Bartenstein, P. [5 ]
Weber, W. A. [6 ]
Schwaiger, M. [6 ]
Morris, J. C. [2 ,7 ]
机构
[1] Univ Hosp LMU Munich, Dept Internal Med 4, Munich, Germany
[2] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA
[3] Ludwig Maximilians Univ Munchen, Ctr Syst Based Drug Res, Dept Pharm, Pharmaceut Biotechnol, Munich, Germany
[4] Ludwig Maximilians Univ Munchen, Ctr Nanosci, Munich, Germany
[5] Univ Hosp LMU Munich, Dept Nucl Med, Munich, Germany
[6] Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, Munich, Germany
[7] Mayo Clin, Div Med Oncol, Rochester, MN USA
关键词
sodium iodide symporter; radioiodine therapy; gene therapy; oncolytic virus; mesenchymal stem cells; polyplexes; reporter gene; therapy gene; ONCOLYTIC VACCINIA VIRUS; MESENCHYMAL STEM-CELLS; TARGETED RADIOIODINE THERAPY; SYSTEMIC NONVIRAL DELIVERY; VESICULAR STOMATITIS-VIRUS; MEASLES-VIRUS; PROSTATE-CANCER; SODIUM/IODIDE SYMPORTER; THYROID-CANCER; I-131; THERAPY;
D O I
10.1530/ERC-21-0177
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy based on image-guided selective NIS gene transfer in non-thyroidal tumors followed by application of I-131 or alternative radionuclides, such as Re-188 and At-211. Over the past two decades, significant progress has been made in the development of the NIS gene therapy concept, from local NIS gene delivery towards promising new applications in disseminated disease, in particular through the use of oncolytic viruses, non-viral polyplexes, and genetically engineered MSCs as highly effective, highly selective and flexible gene delivery vehicles. In addition to allowing the robust therapeutic application of radioiodine in non-thyroid cancer settings, these studies have also been able to take advantage of NIS as a sensitive reporter gene that allows temporal and spatial monitoring of vector biodistribution, replication, and elimination - critically important issues for preclinical development and clinical translation.
引用
收藏
页码:T193 / T213
页数:21
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