SORTI: deciphering the biological and genetic link between cholesterol and coronary heart disease

被引：0
作者：
Musunuru, Kiran [1 ,2 ,3 ,4 ]
机构：
[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Broad Inst MIT & Harvard, Cambridge, MA USA
来源：
CLINICAL LIPIDOLOGY | 2010年 / 5卷 / 06期
关键词：
cardiovascular disease; genetics; genomics; lipids; GENOME-WIDE ASSOCIATION; ARTERY-DISEASE; MYOCARDIAL-INFARCTION; SEQUENCE VARIANTS; BLOOD-LIPIDS; LDL RECEPTOR; LOCI; POPULATION; MUTATIONS; RISK;
D O I：
10.2217/CLP.10.63
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
While the traditional approaches for the identification of disease-causing rare DNA mutations have identified several genes that influence both lipid traits and [coronary heart disease] risk, [genome-wide association studies] appear to have localized as many new genes, including SORTI, which are linked to both phenotypes.
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收藏
页码：765 / 768
页数：4
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