Building mitotic chromosomes

被引：37

作者：

Ohta, Shinya ^{[1
]}

Wood, Laura ^{[1
]}

Bukowski-Wills, Jimi-Carlo ^{[1
]}

Rappsilber, Juri ^{[1
]}

Earnshaw, William C. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 日本学术振兴会;

关键词：

KINETOCHORE-MICROTUBULE ATTACHMENT; DNA TOPOISOMERASE-II; MOLECULAR ARCHITECTURE; CENTROMERE ORGANIZATION; PROTEOME ANALYSIS; CELL-DIVISION; CROSS-LINKING; SMC PROTEINS; CENP-A; CONDENSIN;

D O I：

10.1016/j.ceb.2010.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitotic chromosomes are the iconic structures into which the genome is packaged to ensure its accurate segregation during mitosis. Although they have appeared on countless journal cover illustrations, there remains no consensus on how the chromatin fiber is packaged during mitosis. In fact, work in recent years has both added to existing controversies and sparked new ones. By contrast, there has been very significant progress in determining the protein composition of isolated mitotic chromosomes. Here, we discuss recent studies of chromosome organization and provide an in depth description of the latest proteomics studies, which have at last provided us with a definitive proteome for vertebrate chromosomes.

引用

页码：114 / 121

页数：8

共 93 条

[1]

ADAMS SE, 2002, NUCLEIC ACIDS RES, V30, P5318

[2] ROLE OF NONHISTONE PROTEINS IN METAPHASE CHROMOSOME STRUCTURE [J].

ADOLPH, KW ;

CHENG, SM ;

LAEMMLI, UK .

CELL, 1977, 12 (03) :805-816

[3] Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit [J].

Akiyoshi, Bungo ;

Nelson, Christian R. ;

Ranish, Jeffrey A. ;

Biggins, Sue .

GENES & DEVELOPMENT, 2009, 23 (24) :2887-2899

[4] The mitotic chromosome is an assembly of rigid elastic axes organized by structural maintenance of chromosomes (SMC) proteins and surrounded by a soft chromatin envelope [J].

Almagro, S ;

Riveline, D ;

Hirano, T ;

Houchmandzadeh, B ;

Dimitrov, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5118-5126

[5] The CENP-S complex is essential for the stable assembly of outer kinetochore structure [J].

Amano, Miho ;

Suzuki, Aussie ;

Hori, Tetsuya ;

Backer, Chelsea ;

Okawa, Katsuya ;

Cheeseman, Iain M. ;

Fukagawa, Tatsuo .

JOURNAL OF CELL BIOLOGY, 2009, 186 (02) :173-182

[6] Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells [J].

Amin, Mohammed Abdullahel ;

Matsunaga, Sachihiro ;

Uchiyama, Susumu ;

Fukui, Kiichi .

FEBS LETTERS, 2008, 582 (27) :3839-3844

[7] Nucleolar proteome dynamics [J].

Andersen, JS ;

Lam, YW ;

Leung, AKL ;

Ong, SE ;

Lyon, CE ;

Lamond, AI ;

Mann, M .

NATURE, 2005, 433 (7021) :77-83

[8] Mitotic chromosome structure and condensation [J].

Belmont, Andrew S. .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (06) :632-638

[9] Mitotic chromosome scaffold structure: New approaches to an old controversy [J].

Belmont, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :15855-15857

[10] A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage [J].

Boisvert, Francois-Michel ;

Lam, Yun Wah ;

Lamont, Douglas ;

Lamond, Angus I. .

MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (03) :457-470

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