miRBase: integrating microRNA annotation and deep-sequencing data

被引：2819

作者：

Kozomara, Ana ^{[1
]}

Griffiths-Jones, Sam ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

TARGETS; RESOURCE; RNAS;

D O I：

10.1093/nar/gkq1027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miRBase is the primary online repository for all microRNA sequences and annotation. The current release (miRBase 16) contains over 15 000 microRNA gene loci in over 140 species, and over 17 000 distinct mature microRNA sequences. Deep-sequencing technologies have delivered a sharp rise in the rate of novel microRNA discovery. We have mapped reads from short RNA deep-sequencing experiments to microRNAs in miRBase and developed web interfaces to view these mappings. The user can view all read data associated with a given microRNA annotation, filter reads by experiment and count, and search for microRNAs by tissue- and stage-specific expression. These data can be used as a proxy for relative expression levels of microRNA sequences, provide detailed evidence for microRNA annotations and alternative isoforms of mature microRNAs, and allow us to revisit previous annotations. miRBase is available online at: http://www.mirbase.org/.

引用

页码：D152 / D157

页数：6

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