Chemoselective Synthesis of Novel Heterocyclic [3.3.3]Propellane Derivatives via a One-pot Three-component Reaction

被引：12

作者：

Wang, Jing ^{[1
]}

Liu, Hongzhi ^{[1
]}

Wen, Ren ^{[1
]}

Li, Jie ^{[2
]}

Zhu, Songlei ^{[1
]}

机构：

[1] Xuzhou Med Univ, Dept Chem, Sch Pharm, Xuzhou 221004, Jiangsu, Peoples R China

[2] Zhengda Tianqing Pharmaceut Grp Co LTD, Lianyungang 222062, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2017年 / 35卷 / 09期

关键词：

acenaphthenequinone; oxa-aza[3.3.3]propellane; chemoselectivity; multi-component reaction; MULTICOMPONENT REACTIONS; PROPELLANES; EFFICIENT;

D O I：

10.1002/cjoc.201700103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly chemoselective method for the synthesis of heterocyclic [3.3.3]propellane derivatives was developed via sequential three-component reactions of acenaphthenequinone, malononitrile/cyanoacetate and a variety of 1,3-dicarbonyl compounds under mild conditions in ethanol. A plausible mechanism for this type of reaction was proposed. The value of this method was highlighted by its high selectivity, simple procedures, and good yields.

引用

页码：1463 / 1468

页数：6

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